Advances in Experimental Medicine and Biology

Melanocortins

Multiple Actions and TherapeuticPotential

Editors: Catania, Anna (Ed.)

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  • Spans information on chemistry, pharmacology, distribution, and therapeutic potential of melanocortins
  • Discusses the role played by distinct melanocortin receptors in mediating melanocortin effects
  • The reader gets the latest perspectives on all aspects of the melanocortin molecules: from their amino acid sequences, their receptors, the mechanisms of their action, their roles in physiological and pathological processes
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About this book

It is clear that the melanocortins are of immense academic interest. Further, these molecules have remarkable potential as pharmaceutical agents for treatment of multiple human and veterinary disorders and diseases. The evidence to support academic interest and clinical applications lies in significant part within the chapters of this book, chapters written by noted experts in the field who have worked diligently to understand the molecules and to move them toward clinical applications. I personally believe that the - MSH molecule and its derivatives will be used as routine therapeutics in the very near future. My belief is so strong that I left academia to form a company based on -MSH analogs and have caused millions of dollars to be spent on melanocortin research. Now why would a sane professor pick up such a challenge and enter business, an essential step toward any clinical application? It is the - MSH story that drove me. Consider that - MSH occurs in exactly the same amino acid sequence in humans and in the sea lamprey, an organism unchanged since its appearance during the Pennsylvanian period of the Paleozoic era (about 300 million years ago—way before dinosaurs were to be considered). There is unpublished evidence that the stability of the molecule can be traced back a half billion years. Frankly, I believe that the molecule existed even when single cells began to live together.

About the authors

ANNA CATA NIA, MD, PhD is a director of Center for Preclinical Investigation at Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy. She received her degree in Medicine and Surgery at the University of Milan and postdoctoral degree in Endocrinology and Metabolism at the University of Genoa, Italy. For over a decade she has been visiting scientist at The University of Texas Southwestern Medical Center at Dallas, Texas. During the past 20 years, her research activity has been focused on molecular biology and preclinical testing of melanocortins.

Table of contents (12 chapters)

Table of contents (12 chapters)
  • Structure-Activity Relationships (SAR) of Melanocortin and Agouti-Related (AGRP) Peptides

    Pages 1-18

    Singh, Anamika (et al.)

  • Melanocortin Signalling Mechanisms

    Pages 19-28

    Eves, Paula C. (et al.)

  • Distribution and Function of Melanocortin Receptors within the Brain

    Pages 29-48

    Mountjoy, Kathleen G.

  • Drugs, Exercise, and the Melanocortin-4 Receptor— Different Means, Same Ends: Treating Obesity

    Pages 49-60

    Schaub, Jay W. (et al.)

  • Melanocortins in Brain Inflammation: The Role of Melanocortin Receptor Subtypes

    Pages 61-70

    Muceniece, Ruta (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-4419-6354-3
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4419-6353-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4939-5151-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Melanocortins
Book Subtitle
Multiple Actions and TherapeuticPotential
Editors
  • Anna Catania
Series Title
Advances in Experimental Medicine and Biology
Series Volume
681
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Landes Bioscience and Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-6354-3
DOI
10.1007/978-1-4419-6354-3
Hardcover ISBN
978-1-4419-6353-6
Softcover ISBN
978-1-4939-5151-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XX, 153
Topics