Advances in Experimental Medicine and Biology

Polyploidization and Cancer

Editors: Poon, Randy Y.C. (Ed.)

  • Examines evidence that surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers
  • Reviews progress in unraveling the underlying principles that maintain genome stability
  • Contributors include worldwide leaders in the field
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  • ISBN 978-1-4419-6199-0
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Hardcover $249.99
price for USA in USD
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Softcover $219.99
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  • ISBN 978-1-4939-5143-7
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About this book

Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.

About the authors

Randy Y.C. Poon is a professor of Biochemistry at the Hong Kong University of Science and Technology. He was educated at Tonbridge School and received his Master of Arts degree from St. Catharine’s College at the University of Cambridge. He then studied for a Doctor of Philosophy degree at the University of Cambridge and Cancer Research UK with Tim Hunt, FR S. Dr. Poon conducted postdoctoral training at the Salk Institute with Tony Hunter, FR S. Dr. Poon is a member of Editorial Board of numerous international journals, including the Biochemical Journal and Cancer Biology and Therapy. His research interests focus on understanding the molecular basis of cell cycle control in normal and cancer cells.

Table of contents (9 chapters)

  • Polyploidy, Aneuploidy and the Evolution of Cancer

    Merlo, Lauren M.F. (et al.)

    Pages 1-13

  • Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability

    Ito, Daisuke (et al.)

    Pages 15-26

  • Understanding Cytokinesis Failure

    Normand, Guillaume (et al.)

    Pages 27-55

  • DNA Damage and Polyploidization

    Chow, Jeremy P.H. (et al.)

    Pages 57-71

  • Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization

    Talos, Flaminia (et al.)

    Pages 73-91

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4419-6199-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4419-6198-3
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4939-5143-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Polyploidization and Cancer
Editors
  • Randy Y.C. Poon
Series Title
Advances in Experimental Medicine and Biology
Series Volume
676
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Landes Bioscience and Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-6199-0
DOI
10.1007/978-1-4419-6199-0
Hardcover ISBN
978-1-4419-6198-3
Softcover ISBN
978-1-4939-5143-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XV, 151
Topics