Mitochondria and Cancer

1. Front Matter

   Pages i-xii

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2. Mitochondria and Cancer

   • Kjerstin M. Owens, J. S. Modica-Napolitano, Keshav K. Singh

   Pages 1-21

3. Warburg and his Legacy

   • Michael Ristow, Tim J. Schulz

   Pages 23-38

4. The Lipogenic Switch in Cancer

   • Koen Brusselmans, Johannes V. Swinnen

   Pages 39-59

5. Citrate Metabolism in Prostate and Other Cancers

   • Renty B. Franklin, Leslie C. Costello

   Pages 61-78

6. Integration of Genetic, Proteomic, and Metabolic Approaches in Tumor Cell Metabolism

   • Leslie C. Costello, Renty B. Franklin

   Pages 79-92

7. Mitochondrial Respiration and Differentiation

   • Roberto Scatena, Patrizia Bottoni, Bruno Giardina

   Pages 93-102

8. Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells

   • John G. Pastorino, Jan B. Hoek

   Pages 103-129

9. Energy Generating Pathways and the Tumor Suppressor p53

   • Chad A. Corcoran, Ying Huang, M. Saeed Sheikh

   Pages 131-150

10. Mitochondrial Tumor Suppressors

    • Bora E. Baysal

    Pages 151-162

11. Mitochondria in Hematology

    • Stefanie Zanssen

    Pages 163-191

12. Mitochondria and Oncocytomas

    • J. Lima, V. Máximo, P. Soares, R. Portugal, S. Guimarães, M. Sobrinho-Simões

    Pages 193-209

13. Mitochondria as Targets for Cancer Therapy

    • Stephen J. Ralph, Jiri Neuzil

    Pages 211-249

14. Reversing the Warburg Effect: Metabolic Modulation as a Novel Cancer Therapy

    • Gopinath Sutendra, Evangelos D. Michelakis

    Pages 251-264

15. Mitochondrial Nanotechnology for Cancer Therapy

    • Volkmar Weissig, Gerard G. M. D’Souza, Shing-Ming Cheng, Sarathi Boddapati

    Pages 265-279

16. Back Matter

    Pages 281-289

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Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

• Citrate Metabolism
• Lipogenic Switch
• Mitochondria
• Mitochondrial Nanotechnology
• Mitochondrial Respiration
• Oncocytomas
• Prostate Cancer
• Proteomics
• Warburg
• apoptosis
• tumorigenesis

Policies and ethics