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Tumor-Induced Immune Suppression

Mechanisms and Therapeutic Reversal

Editors: Gabrilovich, Dmitry I., Hurwitz, Arthur A. (Eds.)

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  • Presents a comprehensive overview of different mechanisms of immune dysfunction
  • Discusses a number of new mechanisms that have never been discussed in a monograph report including: T-cell inhibitory molecules and regulatory tolergenic DCs
  • Focus on therapeutic correction of the observed abnormalities
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-0-387-69118-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $169.00
price for USA in USD
  • ISBN 978-1-4419-2400-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Tumor Induced Immune Suppression: Mechanisms and Therapeutic Reversal focuses on the critical question of tumor biology: "Why can tumors escape immune system control?" It also addresses one of the most important problems within the field of clinical oncology: the lack of efficient cancer vaccines. Edited by Dmitry Gabrilovich and Andy Hurwitz, the book is the first attempt at a systematic and comprehensive analysis of the various immunosuppressive mechanisms in cancer. This analysis includes information on:

  • Different surface molecules that mediate T-cell suppression in cancer;
  • The specific roles of dendritic cells, macrophages, and myeloid-derived suppressor cells in tumor non-responsiveness;
  • The contribution of regulatory T cells in the inability of immune systems to mount antitumor response;
  • The role of T-cell signaling and different metabolic pathways in tumor-associated immune suppression.

This volume connects a multitude of different immunosuppressive mechanisms into one cohesive picture. Most of the chapters not only describe the biological phenomena, but also suggest specific approaches to their correction.

This book should be of high interest for researchers in the fields of tumor immunology and general immunology, as well as for those who are involved in clinical oncology and cancer immunotherapy.

Reviews

From the reviews:

"The overall goal of this book is to describe what is currently known about the ways tumors circumvent destruction by the host’s immune system. … The book is targeted at researchers -- immunologists in general and, more specifically, tumor immunologists. It also provides a good source of information for graduate students and postdoctoral fellows. The editors of the book and the authors of the chapters are authorities in the areas they discuss. … a useful addition to the field." (Marion C. Cohen, Doody’s Review Service, August, 2008)


Table of contents (13 chapters)

Table of contents (13 chapters)
  • Immune-Suppressive Mechanisms and Cancer: Understanding the Implications, Paradoxes, and Burning Questions

    Pages 1-5

    Hurwitz, Arthur A. (et al.)

  • Mechanisms of Tumor-Associated T-Cell Tolerance

    Pages 7-27

    Adler, Adam J.

  • Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer

    Pages 29-40

    Yao, Sheng (et al.)

  • Regulatory T Cells in Cancer

    Pages 41-67

    Piconese, Silvia (et al.)

  • Cancer-Induced Signaling Defects in Antitumor T Cells

    Pages 69-100

    Frey, Alan B.

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-0-387-69118-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $169.00
price for USA in USD
  • ISBN 978-1-4419-2400-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tumor-Induced Immune Suppression
Book Subtitle
Mechanisms and Therapeutic Reversal
Editors
  • Dmitry I. Gabrilovich
  • Arthur A. Hurwitz
Copyright
2008
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-69118-3
DOI
10.1007/978-0-387-69118-3
Softcover ISBN
978-1-4419-2400-1
Edition Number
1
Number of Pages
X, 302
Topics