Drug Discovery in Pancreatic Cancer

Models and Techniques

Editors: Han, Haiyong, Grippo, Paul (Eds.)

Free Preview
  • The development of pharmacodynamic endpoint assays and the small animal imaging models are increasingly important
  • The last two chapters review recent developments in this area
see more benefits

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4419-1160-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4419-1159-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4899-8275-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Over the past two decades, tremendous advances have been made in the field of cancer drug discovery, particularly in the area of molecular and genetic models and technologies, many of which have been or are beginning to be applied to the drug discovery process for pancreatic cancer. Drug Discovery in Pancreatic Cancer: Models and Techniques offers the latest development in the application of those models and technologies in pancreatic cancer. The authors include experts in their perspective field of research including basic scientists as well as clinicians who work on the frontline in the war against pancreatic cancer and have first-hand experience employing these cutting-edge tools and techniques. The book progresses logically from modeling systems to genomic profiling, proteomic analysis, and pharmacodynamic assays. It features: • Up-to-date survey of many cell lines and animal models of pancreatic cancer and their applications in drug discovery. • Application of fluorescent mouse models in pancreatic cancer drug discovery. • Utility of cutting-edge genomics, proteomics, epigenomics, and glycomics methodologies for molecular target identification and validation. • Discussion of microRNA profiling and high throughput RNAi screening for pancreatic cancer drug discovery. • Broad screening technologies for proteins and nucleic acids using tissue microarrays and CGH arrays. • Development of pharmacodynamic endpoint assays for targeted therapeutics. Comprehensive and practical Drug Discovery in Pancreatic Cancer: Models and Techniques offers both basic and clinical scientists who are interested in pancreatic cancer an up-to-date review and assessment of models and technologies being applied in drug discovery for pancreatic cancer. The true premise of this book is to provide a guide for drug discovery and evaluation, with consideration of various modeling systems and the methods for screening/profiling responses to these compounds. It is the Editors intent to stimulate new thought in this area of research as a means of generating much improved drug efficacy for greater survival and quality of life for patients battling pancreatic cancer.

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Drug Evaluations in Pancreatic Cancer Culture Systems

    Mullapudi, Bhargava (et al.)

    Pages 1-27

  • Mouse Xenograft Models for Drug Discovery in Pancreatic Cancer

    Rubio-Viqueira, Belen (et al.)

    Pages 29-49

  • Fluorescent Metastatic Mouse Models of Pancreatic Cancer for Drug Discovery

    Bouvet, Michael (et al.)

    Pages 51-72

  • A New Preclinical Paradigm for Pancreas Cancer

    Hingorani, Sunil R.

    Pages 73-93

  • Zebrafish as a Biological System for Identifying and Validating Therapeutic Targets and Compounds

    Yee, Nelson S.

    Pages 95-112

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4419-1160-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4419-1159-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4899-8275-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Drug Discovery in Pancreatic Cancer
Book Subtitle
Models and Techniques
Editors
  • Haiyong Han
  • Paul Grippo
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-1-4419-1160-5
DOI
10.1007/978-1-4419-1160-5
Hardcover ISBN
978-1-4419-1159-9
Softcover ISBN
978-1-4899-8275-9
Edition Number
1
Number of Pages
XIX, 297
Topics