Biological and Medical Physics, Biomedical Engineering

The Physics of Proteins

An Introduction to Biological Physics and Molecular Biophysics

Authors: Frauenfelder, Hans

Editors: Chan, Shirley S., Chan, Winnie S. (Eds.)

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  • The discussion concentrates on physical tools and properties, emphasizing techniques that are contributing to new developments and avoiding those that are already well established and whose results have already been exploited fully
  • New tools appear regularly – synchrotron radiation, proton radiology, holography, optical tweezers, and muon radiography, for example, have all been used to open new areas of understanding
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Softcover $129.99
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About this Textbook

Physics and the life sciences have established new connections within the past few decades, resulting in biological physics as an established subfield with strong groups working in many physics departments. These interactions between physics and biology form a two-way street with physics providing new tools and concepts for understanding life, while biological systems can yield new insights into the physics of complex systems. To address the challenges of this interdisciplinary area, The Physics of Proteins: An Introduction to Biological Physics and Molecular Biophysics is divided into three interconnected sections. In Parts I and II, early chapters introduce the terminology and describe the main biological systems that physicists will encounter. Similarities between biomolecules, glasses, and solids are stressed with an emphasis on the fundamental concepts of living systems. The central section (Parts III and IV) delves into the dynamics of complex systems. A main theme is the realization that biological systems, in particular proteins, do not exist in unique conformations but can assume a very large number of slightly different structures. This complexity is captured in the concept of a free energy landscape and leads to the conclusion that fluctuations are crucial for the functioning of biological systems. The final chapter of this section challenges the reader to apply these concepts to a problem that appears in the current literature. An extensive series of appendices (Part V) provide descriptions of the key physical tools and analytical methods that have proven powerful in the study of the physics of proteins. The appendices are designed to be consulted throughout the section on protein dynamics without breaking the deductive flow of the logic in the central section of the book.

About the authors

A leader in physics research for more than half a century, Hans Frauenfelder spent 40 years as a professor and researcher at the University of Illinois before moving on to Los Alamos Laboratory, where he was the director of the Center for Nonlinear Studies and is now a Laboratory Fellow. Frauenfelder has been elected to the National Academy of Sciences, the American Academy of Arts and Sciences, the Academy Leopoldina and the American Philosophical Society. He also is the recipient of numerous prestigious scientific fellowships and honors.

Reviews

From the reviews:

“It appears to be written for advanced undergraduates and graduates in physics who are newcomers to biophysics and biochemistry. … The book builds from Frauenfelder’s sketches and hand-drawn diagrams, which impart to the volume a personal touch, to its major theme:  Frauenfelder’s insight that protein structures undergo conformational transitions – proteinquakes – through sub-states of approximately equal energy in a rugged, multi-dimensional, conformational-energy landscape.” (H. Richard Leuchtag, Physics Today, May, 2011)

Table of contents (30 chapters)

Table of contents (30 chapters)

Buy this book

eBook $99.00
price for USA in USD (gross)
  • ISBN 978-1-4419-1044-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-1-4419-1043-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.99
price for USA in USD
  • ISBN 978-1-4614-2608-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Physics of Proteins
Book Subtitle
An Introduction to Biological Physics and Molecular Biophysics
Authors
Editors
  • Shirley S. Chan
  • Winnie S. Chan
Series Title
Biological and Medical Physics, Biomedical Engineering
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-1-4419-1044-8
DOI
10.1007/978-1-4419-1044-8
Hardcover ISBN
978-1-4419-1043-1
Softcover ISBN
978-1-4614-2608-0
Series ISSN
1618-7210
Edition Number
1
Number of Pages
XVI, 448
Number of Illustrations
214 b/w illustrations, 7 illustrations in colour
Topics