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Advances in Experimental Medicine and Biology

V(D)J Recombination

Editors: Ferrier, Pierre (Ed.)

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About this book

v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way of understanding how maturelympho­ cytes carry on their basic functions. For the group of aficionados-which includes this editor-it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likelyhijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to generate an immune repertoire and efficient host surveillance while avoiding autoimmunity. Recently, important new refinements in these systems have emerged, continuing to challenge ourknowledge andbeliefs. These arejust thetopics covered by the senior authors-all established leaders in this field-and their colleagues, whilst writing the various chapters in V(D)J Recombination.

About the authors

PIERRE FERRIER is a Principal Investigator and Research Director at the

Centre d’Immunologie de Marseille-Luminy (CIML), France. He has also worked

as a Director of Marseille-Nice Genopole, a local consortium of more than twenty

laboratories aimed at developing high-throughput research techniques in genomics.

Main research interests include the analysis of the molecular mechanisms responsible

for the control of gene expression and recombination programs during hematopoietic

cell development and pathogenesis. He is a member of several national and international

scientific organizations including the Institut National de la Santé et de la

Recherche Médicale (Inserm), the Agence Nationale de la Recherche (ANR), the

Association pour la Recherche sur le Cancer (ARC), the Human Frontier Science

Program Organization (HFSPO), and the Université Virtuelle Médicale de Monaco

(UVMM). Pierre Ferrier received his academic degrees from Montpellier (MD) and

Marseille (PhD) Universities, France. He was a post-doctoral fellow (1986-90) in

the laboratory of Prof. F.W. Alt at the Columbia University College of Physicians

and Surgeons, New York, NY, USA.

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Early Steps of V(D)J Rearrangement: Insights from Biochemical Studies of RAG-RSS Complexes

    Pages 1-15

    Swanson, Patrick C. (et al.)

  • Regulation of RAG Transposition

    Pages 16-31

    Matthews, Adam G. W. (et al.)

  • Recent Insights into the Formation of RAG-Induced Chromosomal Translocations

    Pages 32-45

    Brandt, Vicky L. (et al.)

  • V(D)J Recombination Deficiencies

    Pages 46-58

    Villartay, Jean-Pierre

  • Large-Scale Chromatin Remodeling at the Immunoglobulin Heavy Chain Locus: A Paradigm for Multigene Regulation

    Pages 59-72

    Bolland, Daniel J. (et al.)

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-1-4419-0296-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4419-0295-5
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Softcover $249.99
price for USA in USD
  • ISBN 978-1-4939-0124-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
V(D)J Recombination
Editors
  • Pierre Ferrier
Series Title
Advances in Experimental Medicine and Biology
Series Volume
650
Copyright
2009
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-1-4419-0296-2
DOI
10.1007/978-1-4419-0296-2
Hardcover ISBN
978-1-4419-0295-5
Softcover ISBN
978-1-4939-0124-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVII, 199
Additional Information
Jointly published with Landes Bioscience
Topics