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Handbook on Immunosenescence

basic understanding and clinical applications

  • Book
  • © 2009

Overview

Editors:
  1. Tamas Fulop

    1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada

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  2. Claudio Franceschi

    1. Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Bologna, Italy

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  3. Katsuiku Hirokawa

    1. Institute for Health and Life Sciences, Bunkyo-ku, Tokyo, Japan

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  4. Graham Pawelec

    1. ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Tübingen, Germany

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  • The first comprehensive handbook on immunosenescence
  • First to treat in one volume all the aspects of immunosenescence
  • Bridging bench research and clinical applications
  • Written by internationally recognised people in the field of immunosenescence
  • Useful for anti-aging research and clinic

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Table of contents (77 chapters)

  1. Front Matter

    Pages i-xxxi
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  2. Methods and Models for Studying Immunosenescence

    1. Front Matter

      Pages 2-2
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    2. The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies

      • Anders Wikby, Jan Strindhall, Boo Johansson
      Pages 3-28

    3. Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing

      • Enrico Lugli, Leonarda Troiano, Marcello Pinti, Milena Nasi, Erika Roat, Roberta Ferraresi et al.
      Pages 29-62

    4. Mouse Models and Genetics of Immunosenescence

      • Qing Yu, Jyoti Misra Sen, Dennis Taub
      Pages 63-85

    5. Insect Models of Immunosenescence

      • Jeff Leips
      Pages 87-105

    6. Clonal Culture Models of T-cell Senescence

      • Graham Pawelec, Jürgen Kempf, Anis Larbi
      Pages 107-115

    7. Mouse Models of Influenza

      • Ian C. Brett, Bert E. Johansson
      Pages 117-130

    8. A Transgenic Dwarf Rat Strain as a Tool for the Study of Immunosenescence in Aging Rats and the Effect of Calorie Restriction

      • Isao Shimokawa, Masanori Utsuyama, Toshimitsu Komatsu, Haruyoshi Yamaza, Takuya Chiba
      Pages 131-144

    9. Mathematical Modeling of Immunosenescence: Scenarios, Processes and Limitations

      • A. A. Romanyukha, S. G. Rudnev, T. A. Sannikova, A. I. Yashin
      Pages 145-163

  3. Cellular Immunosenescene - T Cells

    1. Front Matter

      Pages 166-166
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    2. Age, T-cell Homeostasis, and T-cell Diversity in Humans

      • David L Lamar, Cornelia M. Weyand, Jörg J. Goronzy
      Pages 167-192

    3. The Role of T-regulatory Cells in Immune Senescence

      • Paul Moss
      Pages 193-202

    4. Age-related Changes in Subpopulations of Peripheral Blood Lymphocytes in Healthy Japanese Population

      • Masanori Utsuyama, Yuko Kikuchi, Masanobu Kitagawa, Katsuiku Hirokawa
      Pages 203-218

    5. Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance

      • Janko Nikolich-Žugich, Anna Lang
      Pages 219-233

    6. T-cell Cycle and Immunosenescence: Role of Aging in the T-cell Proliferative Behaviour and Status Quo Maintenance

      • Jacek M. Witkowski
      Pages 235-255

    7. Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells of the Elderly and in the T-cell Clone Longitudinal Model

      • Simona Neri, Erminia Mariani
      Pages 257-276

    8. Activation-Induced Cell Death of T-Cells in Elderly

      • Ewa Sikora, Agnieszka Brzezińska
      Pages 277-290

    9. CD8 Clonal Expansions in Mice: An Age-associated Alteration of CD8 Memory T-cells

      • Eric T. Clambey, John W. Kappler, Philippa Marrack
      Pages 291-325

    10. Generation and Gene Expression of CD28-CD8 T-cells in Human

      • Nan-ping Weng
      Pages 327-341
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Keywords

About this book

“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”

Reviews

From the reviews: “The Handbook on Immunosenescence, a 1,650-page 2-volume encyclopedia on aging research with 78 articles, includes 5 sections … . Its strength is the broad coverage of aging, the immune system, and diseases of the elderly. For this reason, the Handbook on Immunosenescence is a worthy addition to any medical library.” (Marc E. Weksler, Gerontology, Vol. 56 (3), March, 2010)

Editors and Affiliations

  • Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada

    Tamas Fulop

  • Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Bologna, Italy

    Claudio Franceschi

  • Institute for Health and Life Sciences, Bunkyo-ku, Tokyo, Japan

    Katsuiku Hirokawa

  • ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Tübingen, Germany

    Graham Pawelec

Bibliographic Information

  • Book Title: Handbook on Immunosenescence

  • Book Subtitle: basic understanding and clinical applications

  • Editors: Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec

  • DOI: https://doi.org/10.1007/978-1-4020-9063-9

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2009

  • Hardcover ISBN: 978-1-4020-9062-2Published: 25 February 2009

  • Softcover ISBN: 978-94-017-7721-6Published: 23 August 2016

  • eBook ISBN: 978-1-4020-9063-9Published: 27 February 2009

  • Edition Number: 1

  • Number of Pages: XXXI, 1693

  • Topics: Biomedicine general, Immunology, Geriatrics/Gerontology

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