Lipids in Health and Disease

1. Front Matter

   Pages I-XXI

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2. Fatty Acids

   1. Front Matter

      Pages 1-1

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   2. Transcriptional Regulation of Hepatic Fatty Acid Metabolism

      • Hervé Guillou, Pascal G.P. Martin, Thierry Pineau

      Pages 3-47

   3. Modulation of Protein Function by Isoketals and Levuglandins

      • Sean S. Davies

      Pages 49-70

   4. Signalling Pathways Controlling Fatty Acid Desaturation

      • María Cecilia Mansilla, Claudia E. Banchio, Diego de Mendoza

      Pages 71-99

   5. Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System

      • Filomena Fezza, Chiara De Simone, Daniele Amadio, Mauro Maccarrone

      Pages 101-132

   6. Modulation of Inflammatory Cytokines by Omega-3 Fatty Acids

      • Jing X. Kang, Karsten H. Weylandt

      Pages 133-143

   7. Eicosanoids in Tumor Progression and Metastasis

      • Sriram Krishnamoorthy, Kenneth V. Honn

      Pages 145-168

   8. Fatty Acid Synthase Activity in Tumor Cells

      • Joy L. Little, Steven J. Kridel

      Pages 169-194

3. Phospholipids

   1. Front Matter

      Pages 195-195

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   2. Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes: Implications for Lipid-linked Disorders

      • Mikhail Bogdanov, Eugenia Mileykovskaya, William Dowhan

      Pages 197-239

   3. Altered Lipid Metabolism in Brain Injury and Disorders

      • Rao Muralikrishna Adibhatla, J. F. Hatcher

      Pages 241-268

   4. Lysophospholipid Activation of G Protein-Coupled Receptors

      • Tetsuji Mutoh, Jerold Chun

      Pages 269-297

   5. Phospholipid-Mediated Signaling and Heart Disease

      • Paramjit S. Tappia, Tushi Singal

      Pages 299-324

   6. The Role of Phospholipid Oxidation Products in Inflammatory and Autoimmune Diseases

      • Norbert Leitinger

      Pages 325-350

   7. Mediation of Apoptosis by Oxidized Phospholipids

      • Gilbert O. Fruhwirth, Albin Hermetter

      Pages 351-367

4. Sphingolipids

   1. Front Matter

      Pages 369-369

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   2. Regulation of lipid metabolism by sphingolipids

      • Tilla S. Worgall

      Pages 371-385

   3. Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis

      • Natasha C. Lucki, Marion B. Sewer

      Pages 387-412

   4. Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics

      • Sahar A. Saddoughi, Pengfei Song, Besim Ogretmen

      Pages 413-440

Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.

• Activation
• Lipid
• Metabolism
• Oxidation
• enzymes
• regulation
• transcription

• Biochemistry Department, King’s College London, UK

  Peter J. Quinn

• State Key Laboratory of Food Science and Technology, Jiangnan University, China

  Xiaoyuan Wang

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