Therapeutic Resistance to Anti-hormonal Drugs in Breast Cancer

New Molecular Aspects and their Potential as Targets

Editors: Hiscox, Stephen, Gee, Julia, Nicholson, Robert I. (Eds.)

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  • Presents a clear and in-depth overview of both the clinical and scientific aspects of endocrine resistance in breast cancer
  • Includes emerging and novel themes in breast cancer resistance development
  • Reports up-to-date scientific and translational advances in this field
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-1-4020-8526-0
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Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4020-8525-3
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Softcover $169.99
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  • ISBN 978-90-481-7901-5
  • Free shipping for individuals worldwide
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About this book

One of the main causes of failure in the treatment of breast cancer is the intrinsic presence of, or development of, drug resistance by the cancer cells. Recent studies on the mechanisms of cancer drug resistance have yielded important information highlighting both how tumour cells may escape these therapeutic constraints and that drug resistance may further impinge on tumour cell functions that may ultimately promote an adverse cell phenotype. New targets have been identified with potential therapeutic applications in resistant breast cancer leading to the subsequent evaluation of inhibitors of these targets in preclinical studies. Importantly, there is increasing evidence from such studies demonstrating the benefit of novel combination strategies as potential avenues for future drug regimens.
Written by experts in the subject area, this book covers the molecular details and functional consequences of endocrine resistance in breast cancer with particular emphasis on the future applications of novel drug combinations that may be utilized to circumvent resistance and improve anti-tumour effects. This book represents a timely publication in the field of breast cancer research, providing current knowledge in the area of drug resistance and will be important reading material for clinicians and researchers alike.

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Experimental Endocrine Resistance: Concepts and Strategies

    Nicholson, Robert I. (et al.)

    Pages 1-26

  • Transcriptional Coactivators and Corepressors in Endocrine Response and Resistance in Breast Cancer

    Ali, Simak

    Pages 27-38

  • The Re-Expression of Estrogen Receptor in Estrogen Receptor-Negative Breast Cancer and Restoration of Anti-Estrogen Responses

    Bayliss, Jill (et al.)

    Pages 39-62

  • The Dark Side of Antihormonal Action in Breast Cancer

    Gee, Julia M.W. (et al.)

    Pages 63-84

  • Influence of the Tumour Microenvironment

    Walker, Rosemary A.

    Pages 85-96

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-1-4020-8526-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4020-8525-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-90-481-7901-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Therapeutic Resistance to Anti-hormonal Drugs in Breast Cancer
Book Subtitle
New Molecular Aspects and their Potential as Targets
Editors
  • Stephen Hiscox
  • Julia Gee
  • Robert I. Nicholson
Copyright
2009
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-8526-0
DOI
10.1007/978-1-4020-8526-0
Hardcover ISBN
978-1-4020-8525-3
Softcover ISBN
978-90-481-7901-5
Edition Number
1
Number of Pages
XII, 204
Topics