The Tumor Microenvironment

Regulation of Gene Expression in the Tumor Environment

Regulation of melanoma progression by the microenvironment: the roles of PAR-1 and PAFR

Editors: Bar-Eli, Menashe (Ed.)

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  • Describes the contribution of the tumor microenvironment to tumor growth and metastasis
  • Gives a unique opportunity to understand the cross talk between tumor cells (the seed) and the organ microenvironment (the soil)
  • Discusses therapy targeting the microenvironment rather than the tumor cells
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eBook $189.00
price for USA in USD (gross)
  • ISBN 978-1-4020-8341-9
  • Digitally watermarked, DRM-free
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4020-8340-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-90-481-7849-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.

Table of contents (7 chapters)

Table of contents (7 chapters)
  • Regulation of Melanoma Progression by the Tumor Microenvironment: The Roles of PAR-1 and PAFR

    Villares, Gabriel J. (et al.)

    Pages 1-10

  • Functions of Autocrine Motility Factor at the Tumor Microenvironment

    Funasaka, Tatsuyoshi (et al.)

    Pages 11-25

  • Targeting Signaling Pathways – In the Search of Melanoma’s Achilles’ Heel

    Haass, Nikolas K. (et al.)

    Pages 27-42

  • The Impact of ErbB2 on Cancer Progression and Metastasis through Modulation of Tumor and Tumor Microenvironment

    Hawthorne, Valerie Stone (et al.)

    Pages 43-56

  • Convergance of Cytoskeletal Signaling at p21-Activated Kinases

    Gururaj, Anupama E. (et al.)

    Pages 57-78

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-1-4020-8341-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4020-8340-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-90-481-7849-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Regulation of Gene Expression in the Tumor Environment
Book Subtitle
Regulation of melanoma progression by the microenvironment: the roles of PAR-1 and PAFR
Editors
  • Menashe Bar-Eli
Series Title
The Tumor Microenvironment
Series Volume
2
Copyright
2008
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-8341-9
DOI
10.1007/978-1-4020-8341-9
Hardcover ISBN
978-1-4020-8340-2
Softcover ISBN
978-90-481-7849-0
Edition Number
1
Number of Pages
X, 148
Topics