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Heat Shock Proteins

Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Editors: Asea, Alexzander A.A., Brown, Ian R. (Eds.)

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  • Written by leaders in the field of neurodegenerative diseases and neuroprotection
  • Provides up-to-date reviews on the most recent concepts of the role of heat shock proteins in repair and protective mechanisms in the brain
  • Contains chapters with in-depth reviews on heat shock proteins and neurodegenerative diseases, heat shock proteins and neuroprotection, extracellular heat shock proteins and the nervous system and aging, as well as control of life span and expression of heat shock proteins
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eBook $249.00
price for USA in USD
  • ISBN 978-1-4020-8231-3
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
Softcover $319.00
price for USA in USD
About this book

With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • Chaperones and Polyglutamine Expansion Disorders

    Pages 3-23

    Duennwald, Martin L.

  • Heat Shock Proteins, Unfolded Protein Response Chaperones and Alzheimer’s Disease

    Pages 25-50

    Magrané, Jordi (et al.)

  • Cellular and Molecular Mechanisms Underlying Parkinson’s Disease: The Role of Molecular Chaperones

    Pages 51-68

    Mclean, Pamela J.

  • Heat Shock Proteins as Therapeutic Targets in Amyotrophic Lateral Sclerosis

    Pages 69-107

    Kalmar, Bernadett (et al.)

  • The Role of Chaperones and Co-Chaperones in Retinal Degenerative Diseases

    Pages 109-123

    Kosmaoglou, Maria (et al.)

Buy this book

eBook $249.00
price for USA in USD
  • ISBN 978-1-4020-8231-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
Softcover $319.00
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection
Editors
  • Alexzander A.A. Asea
  • Ian R. Brown
Series Title
Heat Shock Proteins
Series Volume
3
Copyright
2008
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-8231-3
DOI
10.1007/978-1-4020-8231-3
Hardcover ISBN
978-1-4020-8230-6
Softcover ISBN
978-90-481-7813-1
Series ISSN
1877-1246
Edition Number
1
Number of Pages
XVI, 373
Topics

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