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Progress in Experimental Cardiology

Signal Transduction and Cardiac Hypertrophy

Editors: Dhalla, N.S., Hryshko, L., Kardami, E., Singal, P.K. (Eds.)

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  • ISBN 978-1-4615-0347-7
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About this book

Cellular signaling in cardiac muscle refers to the myriad of stimuli and responses that direct and control the physiological operation of this organ. Our understand­ ing of these complex signaling cascades has increased dramatically over the past few decades with the advent of molecular tools for their dissection. Moreover, this infor­ mation is beginning to provide tangible targets towards manipulating cardiac func­ tion in the setting of cardiovascular disease. The mechanisms and factors that regulate cardiac cell growth are of particular interest as both adaptive and maladaptive responses can occur during cardiac hypertrophy. Cardiac hypertrophy describes the increase in individual cardiac myocyte size that is accomplished through the series and/or parallel addition of sarcomeres. The ability of cardiac muscle to increase in size through hyperplasia becomes highly restricted or negligible shortly after birth. Consequently, the increase in heart size associated with development and growth of an individual occurs through hypertrophy. In response to a chronic increase in workload, cardiac muscle cells can dramatically increase in size to face their increasing contractile demands. While this plasticity is clearly a ben­ eficial response under many conditions, it can be highly deleterious and inappropri­ ate under others. For example, cardiac hypertrophy associated with endurance exercise clearly enhances athletic performance. In contrast, the hypertrophy associated with chronic hypertension, stenotic or regurgitant heart valves, or following a myocardial infarction often continues far beyond the period where this adaptive response is ben­ eficial.

Table of contents (35 chapters)

Table of contents (35 chapters)
  • Molecular Changes of the Myocardium after Mechanical Circulatory Support

    Pages 3-18

    Grabellus, Florian (et al.)

  • Reverse Molecular Remodeling of the Failing Human Heart Following Support with a Left Ventricular Assist Device

    Pages 19-35

    Heerdt, Paul M., M.D., Ph.D. (et al.)

  • Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart

    Pages 37-48

    Cingolani, Dr. Horacio E. (et al.)

  • L-Arginine at the Crossroads of Biochemical Pathways Involved in Myocardial Hypertrophy

    Pages 49-56

    Giordano, Emanuele, MD PhD (et al.)

  • Signal Transduction System in Human Aortic Smooth Muscle Cell Stimulated by Pure Pressure

    Pages 57-67

    Kawaguchi, Hideaki (et al.)

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-4615-0347-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-1-4020-7218-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4613-5032-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Signal Transduction and Cardiac Hypertrophy
Editors
  • Naranjan S Dhalla
  • Larry Hryshko
  • Elissavet Kardami
  • Pawan K. Singal
Series Title
Progress in Experimental Cardiology
Series Volume
7
Copyright
2003
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-0347-7
DOI
10.1007/978-1-4615-0347-7
Hardcover ISBN
978-1-4020-7218-5
Softcover ISBN
978-1-4613-5032-3
Series ISSN
1389-1774
Edition Number
1
Number of Pages
XVII, 508
Topics