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Cancer Treatment and Research

Clinically Relevant Resistance in Cancer Chemotherapy

Editors: Andersson, Borje, Murray, David (Eds.)

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About this book

Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long­ term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.

Table of contents (17 chapters)

  • Tumor Physiology and Resistance to Chemotherapy: Repopulation and Drug Penetration

    Davis, Alison J. (et al.)

    Pages 1-26

  • The Role of Membrane Transporters in Cellular Resistance to Anticancer Nucleoside Drugs

    Clarke, Marilyn L. (et al.)

    Pages 27-47

  • MDR and MRP Gene Families as Cellular Determinant Factors for Resistance to Clinical Anticancer Agents

    Deng, Lei (et al.)

    Pages 49-66

  • The Glutathione System in Alkylator Resistance

    Hamilton, David (et al.)

    Pages 67-87

  • The Role of Signal Transduction Pathways in Drug and Radiation Resistance

    Grant, Steven (et al.)

    Pages 89-108

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-1-4615-1173-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-1-4020-7200-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.99
price for USA in USD
  • ISBN 978-1-4613-5428-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Clinically Relevant Resistance in Cancer Chemotherapy
Editors
  • Borje Andersson
  • David Murray
Series Title
Cancer Treatment and Research
Series Volume
112
Copyright
2002
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-1173-1
DOI
10.1007/978-1-4615-1173-1
Hardcover ISBN
978-1-4020-7200-0
Softcover ISBN
978-1-4613-5428-4
Series ISSN
0927-3042
Edition Number
1
Number of Pages
XX, 380
Topics