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Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications

  • Book
  • © 2002

Overview

Editors:
  1. J.-C. Fruchart

    1. Faculté des Sciences Pharmaceutiques et Biologiques, Inserm U 545, Dept. Atherosclerose, Institut Pasteur de Lille, Université de Lille II, Lille, France

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  2. A. M. Gotto

    1. Weill Medical College of Cornell University, New York, USA

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  3. R. Paoletti

    1. Department of Pharmacological Sciences, University of Milan, Milan, Italy

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  4. B. Staels

    1. Department of Atherosclerosis, Pasteur Institute, Inserm U 545, University of Lille II, Lille, France

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  5. A. L. Catapano

    1. Department of Pharmacological Sciences, University of Milan, Milan, Italy

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Part of the book series: Medical Science Symposia Series (MSSS, volume 18)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Structure, Function, and Molecular Mechanisms of PPAR Action

    1. Peroxisome Proliferator Activated Receptor Alpha Coordinates Intermediary Metabolism During Fasting

      • Sander Kersten, Béatrice Desvergne, Walter Wahli
      Pages 1-4

    2. Design, Structure, and Function of Novel PPAR Ligands

      • Timothy M. Willson, Millard H. Lambert, H. Eric Xu
      Pages 5-8

    3. Functions of PPAR Gamma in Macrophages and Atherosclerosis

      • Ajay Chawla, Chih-Hao Lee, Yaacov Barak, Debbie Liao, Ronald M. Evans
      Pages 9-16

  3. Inflammation and Atherosclerosis

    1. PPARs and Atherogenesis: Mediators or Modulators of the Inflammatory Response in the Vessel Wall?

      • Nikolaus Marx
      Pages 17-24

    2. Role of PPARs in Inflammation, Atherosclerosis, and Thrombosis

      • Antoine Pilon, Hélène Duez, Jean-Charles Fruchart, Bart Staels
      Pages 25-34

    3. Effects of Thiazolidinediones on Vascular Reactivity and Endothelial Dysfunction

      • Edward S. Horton, A. Enrique Caballero, Rola Saouaf, Aristidis Veves
      Pages 35-40

  4. PPARγ and α as Therapeutic Targets in Diabetes

    1. Activation of Human PPAR Subtypes by Pioglitazone

      • Hiroyuki Kimura, Junichi Sakamoto, Shinji Moriyama, Hiroyuki Odaka, Yu Momose, Yasuo Sugiyama et al.
      Pages 41-47

    2. PPARγ Mechanism of Action Studies

      • Steven Kliewer
      Pages 49-53

  5. Animal Models to Study PPAR Functions

    1. The Role of PPARα in Fatty Acid Metabolism and Hepatocarcinogenesis: Studies with PPARα-Null Mice

      • Frank J. Gonzalez
      Pages 55-62

  6. PPARα: From Basic Science to Clinical Applications

    1. PPARα, Lipoprotein Metabolism, Metabolic Diseases, and Atherosclerosis

      • Jean-Charles Fruchart, Bart Staels, Patrick Duriez
      Pages 63-79

    2. PPARα and Atherosclerosis

      • Jorge Plutzky
      Pages 81-87

    3. Regulation of CD36 by PPARγ: Pro- or Antiatherogenic?

      • Maria Febbraio, Antonio M. Gotto Jr., Jihong Han, Andrew C. Nicholson, Kavita Sharma, Eugene A. Podrez et al.
      Pages 89-94

  7. Lipid and Lipoprotein Metabolism and Atherosclerosis

    1. Anti-Inflammatory Properties of High Density Lipoproteins

      • Philip Barter, Paul Baker, Jennifer Gamble, Mathew Vadas, Kerry-Anne Rye
      Pages 95-101

  8. The Importance of Raising HDL: From PPARα to Clinical Implications

    1. The Low-HDL Syndrome: Epidemiology and Pathophysiology

      • Guido Franceschini, Barbara Villa, Monica Gomaraschi, Laura Calabresi
      Pages 103-108

    2. Diabetes: A Growing CHD Epidemic

      • Anders Hamsten, George Steiner, Diabetes Atherosclerosis Intervention Study Investigators
      Pages 109-114

  9. Adipose tissue, Obesity, and Diabetes

    1. Influence of PPARs on Muscle Lipid Metabolism and Insulin Resistance

      • Edward W. Kraegen, Gregory J. Cooney, Jiming Ye, Stuart M. Furler
      Pages 115-122

    2. PPARγ in Adipogenesis and Insulin Resistance

      • Stephen R. Farmer, Jonathan K. Hamm, Bae-Hang Park
      Pages 123-130

  10. PPARδ Function and Biology

    1. Pharmacology of a Selective Peroxisome Proliferator-Activated Receptor δ Agonist, GW501516, in Obese Dyslipidemic Primates

      • William Oliver Jr., Dan Sternbach, Barbara Hansen, Timothy Willson
      Pages 131-134

  11. PPARγ: From Basic Science to Clinical Applications

    1. PPARγ: A Regulator of Growth and Differentiation

      • Stephen R. Farmer, Deepanwita Prusty, Ron F. Morrison, Marthe Moldes
      Pages 135-141
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Keywords

About this book

Peroxisome Proliferator Activated Receptors (PPARs) attract great attention in light of the wide spectrum of genes of biological and medical relevance identified as under their control. As a consequence, our knowledge of the role of these receptors in physiology and pathology continues to grow at a fast pace and PPARs have become an interesting target for the treatment of many pathological conditions, including diabetes and atherosclerosis. This volume provides an authoritative view of the current clinical and scientific developments within this evolving area of study.

Editors and Affiliations

  • Faculté des Sciences Pharmaceutiques et Biologiques, Inserm U 545, Dept. Atherosclerose, Institut Pasteur de Lille, Université de Lille II, Lille, France

    J.-C. Fruchart

  • Weill Medical College of Cornell University, New York, USA

    A. M. Gotto

  • Department of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti, A. L. Catapano

  • Department of Atherosclerosis, Pasteur Institute, Inserm U 545, University of Lille II, Lille, France

    B. Staels

Bibliographic Information

  • Book Title: Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications

  • Editors: J.-C. Fruchart, A. M. Gotto, R. Paoletti, B. Staels, A. L. Catapano

  • Series Title: Medical Science Symposia Series

  • DOI: https://doi.org/10.1007/978-1-4615-1171-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 2002

  • Hardcover ISBN: 978-1-4020-7199-7Published: 30 November 2002

  • Softcover ISBN: 978-1-4613-5427-7Published: 14 October 2012

  • eBook ISBN: 978-1-4615-1171-7Published: 06 December 2012

  • Series ISSN: 0928-9550

  • Edition Number: 1

  • Number of Pages: XVI, 172

  • Topics: Biochemistry, general, Cell Biology, Cardiology, Internal Medicine, Pharmacology/Toxicology

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