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Metastasis of Prostate Cancer

  • Book
  • © 2007

Overview

Editors:
  1. Richard J. Ablin

    1. University of Arizona College of Medicine, and the Arizona Cancer Center, Tucson, U.S.A

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    You can also search for this editor in PubMed   Google Scholar

  2. Malcolm D. Mason

    1. University of Cardiff, U.K

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    You can also search for this editor in PubMed   Google Scholar

  • Brings together experts from the laboratory and the clinic
  • Highlights the key areas of active, current, translational research
  • Resource for physicians and/or and scientists involved in the study of prostate cancer and the progression and metastization of the disease

Part of the book series: Cancer Metastasis - Biology and Treatment (CMBT, volume 10)

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Table of contents (16 chapters)

  1. Front Matter

    Pages I-XIV
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  2. Introduction: Metastasis as a Therapeutic Target

    • Richard J. Ablin, Malcolm D. Mason
    Pages 1-3

  3. The Natural History of Prostate Cancer

    • David F. Penson, Peter C. Albertsen
    Pages 5-19

  4. The Search for Genes Which Influence Prostate Cancer Metastasis: A Moving Target?

    • Norman J. Maitland
    Pages 21-61

  5. Polyunsaturated Fatty Acids and Prostate Cancer Metastasis

    • Wen G. Jiang
    Pages 63-85

  6. Role of Prostaglandin Synthesis and Cyclooxygenase-2 in Prostate Cancer and Metastasis

    • Alaa F. Badawi
    Pages 87-109

  7. Cell Cycle Regulation

    • Ruchi M. Newman, Bruce R. Zetter
    Pages 111-125

  8. Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity

    • Mary J.C. Hendrix, Jun Luo, Elisabeth A. Seftor, Navesh Sharma, Paul M. Heidger Jr., Michael B. Cohen et al.
    Pages 127-141

  9. Orthotopic Metastatic Mouse Models of Prostate Cancer

    • Robert M. Hoffman
    Pages 143-169

  10. β-Catenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancer

    • Gaynor Davies, Gregory M. Harrison, Malcolm D. Mason
    Pages 171-196

  11. Hepatocyte Growth Factor/Scatter Factor and Prostate Cancer Metastasis

    • Gaynor Davies, Wen G. Jiang, Malcolm D. Mason
    Pages 197-219

  12. Matrix Degradation in Prostate Cancer

    • Michael J. Wilson, Akhouri A. Sinha
    Pages 221-251

  13. The Biology of Bone Metastases from Prostate Cancer and the Role of Bisphosphonates

    • Noel W. Clarke, Herbert A. Fleisch
    Pages 253-281

  14. Hormone Therapy For Prostate Cancer

    • Mike Shelley, Charles L. Bennett, Derek Nathan, Oliver Sartor
    Pages 283-307

  15. Strategies for the Implementation of Chemotherapy and Radiotherapy

    • Paula Scullin, Joe M. O’Sullivan, Christopher C. Parker
    Pages 309-335

  16. Immuno-gene Therapy for Metastatic Prostate Cancer

    • Takefumi Satoh, Terry L. Timme, Yehoshua Gdor, Brian J. Miles, Robert J. Amato, Dov Kadmon et al.
    Pages 337-353

  17. Distilling the Past – Envisioning the Future

    • Richard J. Ablin, Malcolm D. Mason
    Pages 355-397

  18. Back Matter

    Pages 399-407
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Keywords

About this book

Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g. , 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP ; Integrin ; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows.

Editors and Affiliations

  • University of Arizona College of Medicine, and the Arizona Cancer Center, Tucson, U.S.A

    Richard J. Ablin

  • University of Cardiff, U.K

    Malcolm D. Mason

Bibliographic Information

  • Book Title: Metastasis of Prostate Cancer

  • Editors: Richard J. Ablin, Malcolm D. Mason

  • Series Title: Cancer Metastasis - Biology and Treatment

  • DOI: https://doi.org/10.1007/978-1-4020-5847-9

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2007

  • Hardcover ISBN: 978-1-4020-5846-2Published: 18 July 2007

  • Softcover ISBN: 978-94-017-8152-7Published: 23 November 2014

  • eBook ISBN: 978-1-4020-5847-9Published: 05 September 2007

  • Series ISSN: 1568-2102

  • Series E-ISSN: 2215-1648

  • Edition Number: 1

  • Number of Pages: XIV, 407

  • Topics: Cancer Research, Oncology

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