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Killer Lymphocytes

Authors: Berke, Gideon, Clark, William R.

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  • ISBN 978-1-4020-3270-7
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About this book

The existence of a unique kind of immune cell – the killer lymphocyt- which destroys other cells in a highly specific manner, has fascinated immunologists for almost half a century. How do these cells, whose precursors have lived in communal harmony with their host, decide that some of their cohabitants must die? And how do they kill them? The definition of killer lymphocytes came from discovery of their roles in a wide range of in vivo phenomena such as transplant rejection, virus infection and its related immunopathologies, and anti-tumor responses. Yet for the most part almost everything we know about these cells has come from studying them in vitro. They have yielded their secrets slowly and reluctantly. To understand fully how they work, geneticists and immunologists had to unravel the major histocompatibility systems of vertebrates, a long and torturous road that provided some of the darkest hours of immunology. The search for antigen-sensing receptors on both T cells and NK cells was scarcely less frustrating. And the holy grail of ce- mediated cytotoxicity – defining the mechanism by which killer cells take down their adversaries – sorely tested the ingenuity, patience and mutual good will of laboratories around the world. These questions have now largely been answered. But do we really understand these cells? We can tame them to a large degree in transplant rejection. It may yet turn out that we can harness their immunotherapeutic potential in treating viral and malignant disease.

Table of contents (11 chapters)

Table of contents (11 chapters)
  • Basic Immunobiology: A Primer

    Pages 1-28

  • Cytotoxic T Lymphocytes: Generation and Cellular Properties

    Pages 29-52

  • Cytotoxic T Lymphocytes: Target Cell Recognition and Binding

    Pages 53-69

  • Cytotoxic T Lymphocytes: Target Cell Killing: Cellular Parameters

    Pages 71-93

  • Cytotoxic T Lymphocytes: Target Cell Killing: Molecular mechanisms

    Pages 95-123

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-1-4020-3270-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA in USD
  • ISBN 978-1-4020-3269-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $119.00
price for USA in USD
  • ISBN 978-1-4020-6563-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Killer Lymphocytes
Authors
Copyright
2007
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-3270-7
DOI
10.1007/978-1-4020-3270-7
Hardcover ISBN
978-1-4020-3269-1
Softcover ISBN
978-1-4020-6563-7
Edition Number
1
Number of Pages
VIII, 361
Topics