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25 Years of p53 Research

Editors: Hainaut, Pierre, Wiman, Klas G. (Eds.)

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About this book

1. Communication, awareness and access to information: Given the complexity of the field and the fact that data pertaining to each particular aspects of p53 biology or deregulation are scattered in many different publications, it is extremely difficult to access the full scale of relevant information of any specific p53-related topic. Review arcticles, despite their fundamental role in disseminating knowledge, usually focus only on general mechanisms and do not discuss in detail the many variations that can occur with respect to cell type, particular mutation type, as well as biological activation context. Books such as this one may help in this task by putting into perspective both general considerations on the p53 pathway and more specific information on various aspects of p53. In the longer term, however, open access to p53 complexity will require the development of knowledge bases accessible through the web and using simple navigation tools to guide users towards the specific information they need. Several efforts are currently being developed in that direction. They need to be strenghtened and better integrated within the rapidly growing galaxy of web-based information sources on molecular and individual variations in cancer. 2. Reference functional assays and structural analysis: Given the huge diversity of cellular and animal models for wild-type or mutant p53 functions, it will be important to set up standard, universally accepted assays to measure critical p53 protein functions.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • The First Twenty-Five Years of p53 Research

    Pages 1-25

    Robins, Harlan (et al.)

  • Regulation of p53 DNA Binding

    Pages 27-51

    McKinney, Kristine (et al.)

  • 20 Years of DNA Damage Signaling to p53

    Pages 53-71

    McLure, Kevin G. (et al.)

  • Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX

    Pages 73-113

    Wahl, Geoffrey M. (et al.)

  • Regulation of the p53 Response by Cellular Growth and Survival Factors

    Pages 115-140

    Brown, Lauren (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-1-4020-2922-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4020-2920-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.99
price for USA in USD
  • ISBN 978-1-4020-6564-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
25 Years of p53 Research
Editors
  • Pierre Hainaut
  • Klas G. Wiman
Copyright
2005
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-2922-6
DOI
10.1007/978-1-4020-2922-6
Hardcover ISBN
978-1-4020-2920-2
Softcover ISBN
978-1-4020-6564-4
Edition Number
1
Number of Pages
XII, 446
Topics