Proteases and Their Inhibitors in Cancer Metastasis

1. Front Matter

   Pages i-vi

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2. Molecular Biology of the Plasminogen System: The Delicate Balance between Tissue Healing and Tissue Destruction

   • A. Luttun, P. Carmeliet

   Pages 1-22

3. Role of Serine Proteases and their Inhibitors in Tumor Growth and Angiogenesis

   • A. Noël, J.-M. Foidart

   Pages 23-38

4. The Gelatinases, MMP-2 and MMP-9-Implications for Invasion and Metastasis

   • Ruth J. Muschel, Jiang Yong

   Pages 39-52

5. The Collagenases: Novel Roles for Matrix Metalloproteinases (MMPS) in Invasion and Metastasis

   • Constance E. Brinckerhoff, Ulrike Benbow, Grant B. Tower

   Pages 53-79

6. Stromelysin-3, a Particular Member of the Matrix Metalloproteinase Family

   • M.-C. Rio

   Pages 81-107

7. Membrane-Type Matrix Metalloproteinases

   • Yoshifumi Itoh, Motoharu Seiki

   Pages 109-125

8. 3D Structure and Drug Design

   • J. Schröder, H. Wenzel, H. Tschesche

   Pages 127-150

9. Transcriptional Control of Proteases

   • H. Allgayer, E. Lengyel, D. D. Boyd

   Pages 151-168

10. Tissue Inhibitors of Metalloproteinases in Cancer

    • Yves A. DeClerck

    Pages 169-194

11. Clinical Aspects of Matrix Metalloproteinases

    • Béatrice Nawrocki-Raby, Christine Clavel, Myriam Polette, Philippe Birembaut

    Pages 195-204

12. Tissue Models to Study Tumor-Stroma Interactions

    • N. E. Fusenig, M. Skobe, S. Vosseler, M. Hansen, W. Lederle, K. Airola et al.

    Pages 205-223

13. Mammalian Heparanase: Molecular Properties, Inhibition and Involvement in Tumor Metastasis and Angiogenesis

    • I. Vlodavsky, Y. Friedmann, M. Elkin, O. Pappo, I Pecker, M. D. Hulett et al.

    Pages 225-252

14. Back Matter

    Pages 253-256

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In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account.
This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.

• angiogenesis
• cancer treatment
• drug design
• metastasis
• molecular biology
• tumor
• tumor growth

• Laboratoire de Biologie des Tumeurs et du Développement, Faculté de Médecine Université de Liège, Belgium

  Jean-Michel Foidart

• Department of Pathology & Laboratory Medicine, University of Pennsylvania, USA

  Ruth J. Muschel

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