Cancer Metastasis - Biology and Treatment

Proteases and Their Inhibitors in Cancer Metastasis

Editors: Foidart, J-M., Muschel, R.J. (Eds.)

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  • ISBN 978-1-4020-2008-7
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About this book

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account.
This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.

Table of contents (12 chapters)

Table of contents (12 chapters)
  • Molecular Biology of the Plasminogen System: The Delicate Balance between Tissue Healing and Tissue Destruction

    Luttun, A. (et al.)

    Pages 1-22

  • Role of Serine Proteases and their Inhibitors in Tumor Growth and Angiogenesis

    Noël, A. (et al.)

    Pages 23-38

  • The Gelatinases, MMP-2 and MMP-9-Implications for Invasion and Metastasis

    Muschel, Ruth J. (et al.)

    Pages 39-52

  • The Collagenases: Novel Roles for Matrix Metalloproteinases (MMPS) in Invasion and Metastasis

    Brinckerhoff, Constance E. (et al.)

    Pages 53-79

  • Stromelysin-3, a Particular Member of the Matrix Metalloproteinase Family

    Rio, M.-C.

    Pages 81-107

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-1-4020-2008-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4020-0923-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-90-481-6142-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Proteases and Their Inhibitors in Cancer Metastasis
Editors
  • J-M. Foidart
  • R.J. Muschel
Series Title
Cancer Metastasis - Biology and Treatment
Series Volume
4
Copyright
2002
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4020-2008-7
DOI
10.1007/1-4020-2008-2
Hardcover ISBN
978-1-4020-0923-5
Softcover ISBN
978-90-481-6142-3
Series ISSN
1568-2102
Edition Number
1
Number of Pages
VI, 256
Topics