Methods in Molecular Biology

Computational Design of Membrane Proteins

Editors: Moreira, Irina S., Machuqueiro, Miguel, Mourão, Joana (Eds.)

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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About this book

This volume provides an overview of the current successes as well as pitfalls and caveats that are hindering the design of membrane proteins. Divided into six parts, chapters detail membrane transporter, FoldX force field, protein stability, G-Protein Coupled Receptors (GPCR) structures, transmembrane helices, membrane molecular dynamics (MD) simulations, pH-dependent protonation states, membrane permeability, and passive transport. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and cutting-edge,  Computational Design of Membrane Proteins aims to ensure successful results in the further study of this vital field.

Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.





Table of contents (16 chapters)

Table of contents (16 chapters)
  • Guardians of the Cell: State-of-the-Art of Membrane Proteins from a Computational Point-of-View

    Pages 3-28

    Rosário-Ferreira, Nícia (et al.)

  • Integrating Membrane Transporter Proteins into Droplet Interface Bilayers

    Pages 31-41

    Findlay, Heather E. (et al.)

  • Membrane Protein Engineering with Rosetta

    Pages 43-57

    Alford, Rebecca F. (et al.)

  • Engineering of Biological Pathways: Complex Formation and Signal Transduction

    Pages 59-70

    Junk, Philipp (et al.)

  • Homology Modeling of Class A G-Protein-Coupled Receptors in the Age of the Structure Boom

    Pages 73-97

    Tiss, Asma (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-0716-1468-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-0716-1467-9
  • with online files
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Computational Design of Membrane Proteins
Editors
  • Irina S. Moreira
  • Miguel Machuqueiro
  • Joana Mourão
Series Title
Methods in Molecular Biology
Series Volume
2315
Copyright
2021
Publisher
Springer US
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-0716-1468-6
DOI
10.1007/978-1-0716-1468-6
Hardcover ISBN
978-1-0716-1467-9
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 290
Number of Illustrations
4 b/w illustrations, 53 illustrations in colour
Topics