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Methods in Pharmacology and Toxicology

Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery

Editors: Rosania, Gus R., Thurber, Greg M. (Eds.)

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Features information that applies to a wide array of research areas
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  • ISBN 978-1-0716-1250-7
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Hardcover $219.99
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  • ISBN 978-1-0716-1249-1
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About this book

This thorough book explores some of the most important methods and concepts affecting the quantitative analysis of the transport, targeting, and disposition of chemicals within cells, which in turn impact the macroscopic pharmacokinetics of chemical agents in the whole organism. The first half of the volume focuses on small organic molecules with drug-like characteristics, while the second half delves into the cellular pharmacokinetics of biologics and other macromolecules, including peptide therapeutics, cyclotides, antibodies, as well as nanoparticles, thus creating a comprehensive treatise that approaches cellular pharmacokinetics from the different perspectives of pharmaceutical scientists, chemical biologists, medicinal chemists, and protein engineers dealing with very different chemical agents spanning a wide range of sizes, physicochemical properties, and targeting mechanisms. Written for the Methods in Pharmacology and Toxicology series, chapters provide the kind of key detail and expert implementation advice that leads to excellent results in the lab. Synthetic biologists, biophysicists, and bioengineers are amongst the long list of scientists who could benefit from reading this book or from using it as a textbook. 
Authoritative and practical, Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery builds on a long history of drug development and the adding of quantitative methods at the cellular scale in order to inspire new approaches to drug development that are better able to take advantage of phenomena such as soluble-to-insoluble phase transitions or bispecific targeting, which could ultimately be exploited for the development of more effective drug delivery systems and therapeutic agents.

Table of contents (18 chapters)

Table of contents (18 chapters)
  • Measurement of Transcellular Transport Rates and Intracellular Drug Sequestration in the Presence of an Extracellular Concentration Gradient

    Pages 3-39

    Min, Kyoung Ah (et al.)

  • Kinetic Design for Establishing Long-Term Stationary Cytosol Concentrations During Drug Transport across P-gp Expressing Confluent Cell Monolayers to Facilitate Measuring Cytosol Concentration, Fitting Drug Molar Partition Coefficients into the Cytosolic Monolayer of the Plasma Membrane, and Kinetically Identifying Drug Uptake Transporters

    Pages 41-65

    Bentz, Joe

  • In Vitro Methodologies to Assess Potential for Transporter-Mediated Drug–Drug Interactions

    Pages 67-80

    Li, Jibin (et al.)

  • Determination of Fraction Unbound and Unbound Partition Coefficient to Estimate Intracellular Free Drug Concentration

    Pages 81-96

    Ryu, Sangwoo (et al.)

  • Quantitative Analysis of Intracellular Drug Concentrations in Hepatocytes

    Pages 97-125

    Saran, Chitra (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-0716-1250-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-0716-1249-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery
Editors
  • Gus R. Rosania
  • Greg M. Thurber
Series Title
Methods in Pharmacology and Toxicology
Copyright
2021
Publisher
Springer US
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-0716-1250-7
DOI
10.1007/978-1-0716-1250-7
Hardcover ISBN
978-1-0716-1249-1
Series ISSN
1557-2153
Edition Number
1
Number of Pages
XVII, 453
Number of Illustrations
18 b/w illustrations, 91 illustrations in colour
Topics