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Clinical Epidemiology

Practice and Methods

  • Book
  • © 2021

Overview

Editors:
  1. Patrick S. Parfrey

    1. Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Brendan J. Barrett

    1. Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2249)

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Table of contents (34 protocols)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. On Framing the Research Question and Choosing the Appropriate Research Design

    • Patrick S. Parfrey, Pietro Ravani
    Pages 1-16

  3. Bias in Clinical Research

    • Susan Stuckless, Patrick S. Parfrey
    Pages 17-34

  4. Definitions of Bias in Clinical Research

    • Geoffrey Warden
    Pages 35-52

  5. Research Ethics for Clinical Researchers

    • John D. Harnett
    Pages 53-64

  6. Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics Research

    • Daryl Pullman, Holly Etchegary
    Pages 65-82

  7. Longitudinal Studies 1: Determinants of Risk

    • Sean W. Murphy
    Pages 83-101

  8. Longitudinal Studies 2: Modeling Data Using Multivariate Analysis

    • Pietro Ravani, Brendan J. Barrett, Patrick S. Parfrey
    Pages 103-124

  9. Longitudinal Studies 3: Data Modeling Using Standard Regression Models and Extensions

    • Pietro Ravani, Brendan J. Barrett, Patrick S. Parfrey
    Pages 125-165

  10. Longitudinal Studies 4: Matching Strategies to Evaluate Risk

    • Matthew T. James
    Pages 167-177

  11. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease

    • Navdeep Tangri, Claudio Rigatto
    Pages 179-191

  12. Randomized Controlled Trials 1: Design

    • Bryan M. Curtis, Brendan J. Barrett, Patrick S. Parfrey
    Pages 193-211

  13. Randomized Controlled Trials 2: Analysis

    • Robert N. Foley, Patrick S. Parfrey
    Pages 213-227

  14. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes

    • Michelle M. Richardson, Klemens B. Meyer
    Pages 229-245

  15. Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality-of-Life Studies

    • Robert N. Foley, Patrick S. Parfrey
    Pages 247-259

  16. Randomized Controlled Trials 5: Biomarkers and Surrogates/Outcomes

    • Claudio Rigatto, Brendan J. Barrett
    Pages 261-280

  17. Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort Studies

    • Tom Greene
    Pages 281-305

  18. Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect

    • Patrick S. Parfrey
    Pages 307-318

  19. Evaluation of Diagnostic Tests

    • Brendan J. Barrett, John M. Fardy
    Pages 319-333

  20. Genetic Epidemiology of Complex Phenotypes

    • Darren D. O’Rielly, Proton Rahman
    Pages 335-367
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Keywords

About this book

This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls.


Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system.




Editors and Affiliations

  • Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada

    Patrick S. Parfrey, Brendan J. Barrett

Bibliographic Information

  • Book Title: Clinical Epidemiology

  • Book Subtitle: Practice and Methods

  • Editors: Patrick S. Parfrey, Brendan J. Barrett

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-1138-8

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1137-1Published: 20 April 2021

  • Softcover ISBN: 978-1-0716-1140-1Published: 20 April 2022

  • eBook ISBN: 978-1-0716-1138-8Published: 19 April 2021

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 3

  • Number of Pages: XIII, 650

  • Number of Illustrations: 53 b/w illustrations, 37 illustrations in colour

  • Topics: Molecular Medicine, Epidemiology

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