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Viruses as Therapeutics

Methods and Protocols

  • Book
  • © 2021

Overview

Editors:
  1. Alexandra R. Lucas

    1. The Biodesign Institute, Arizona State University, Tempe, USA

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2225)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Viruses for Landscape-Scale Therapy: Biological Control of Rabbits in Australia

    • Peter J. Kerr, Robyn N. Hall, Tanja Strive
    Pages 1-23

  3. Development and Expression of Subunit Vaccines Against Viruses in Plants

    • Adrian Esqueda, Qiang Chen
    Pages 25-38

  4. Development of Antiviral Vaccine Utilizing Self-Destructing Salmonella for Antigen and DNA Vaccine Delivery

    • Wei Kong
    Pages 39-61

  5. Methods for the Construction of Recombinant Oncolytic Myxoma Viruses

    • Lino E. Torres-Domínguez, Ana Lemos de Matos, Masmudur M. Rahman, Grant McFadden
    Pages 63-75

  6. Molecular Design and Production of AAV Viral Vectors for Gene Therapy

    • Raela B. Ridley, Erin M. Walsh, Cristhian J. Ildefonso
    Pages 77-92

  7. Murine Model of Thermal Burn Injury for Evaluating Protein Therapeutics Derived from Viruses

    • Gabriella S. Stuart, Nicola C. Jones, Lyn M. Wise
    Pages 93-105

  8. Deriving Immune-Modulating Peptides from Viral Serine Protease Inhibitors (Serpins)

    • Jordan R. Yaron, Liqiang Zhang, Michelle Burgin, Lauren N. Schutz, Enkidia A. Awo, Shahar Keinan et al.
    Pages 107-123

  9. Methods for Crystallization and Structural Determination of M-T7 Protein from Myxoma Virus

    • Christopher Gisriel, Petra Fromme, Jose M. Martin-Garcia
    Pages 125-162

  10. Microscopic Analysis of Viral Infection

    • Honor L. Glenn, Ana Lemos de Matos, Nancy Villa, Grant McFadden
    Pages 163-177

  11. Metabolomics Analysis of Viral Therapeutics

    • Haiwei Gu, Xiaojian Shi, Paniz Jasbi, Jeffrey Patterson
    Pages 179-197

  12. Detecting Necroptosis in Virus-Infected Cells

    • Samantha M. Cotsmire, Mateusz Szczerba, Bertram L. Jacobs
    Pages 199-216

  13. Topical Application of Virus-Derived Immunomodulating Proteins and Peptides to Promote Wound Healing in Mouse Models

    • Liqiang Zhang, Jordan R. Yaron, Qiuyun Guo, Jacquelyn Kilbourne, Enkidia A. Awo, Michelle Burgin et al.
    Pages 217-226

  14. Neurologic and Histologic Tests Used to Measure Neuroprotective Effectiveness of Virus-Derived Immune-Modulating Proteins

    • Jacek M. Kwiecien, Jordan R. Yaron, Kathleen H. Delaney, Alexandra R. Lucas
    Pages 227-239

  15. Preclinical Testing of Viral Therapeutic Efficacy in Pristane-Induced Lupus Nephritis and Diffuse Alveolar Hemorrhage Mouse Models

    • Qiuyun Guo, Liqiang Zhang, Jordan R. Yaron, Michelle Burgin, Lauren N. Schutz, Enkidia A. Awo et al.
    Pages 241-255

  16. Kidney Subcapsular Allograft Transplants as a Model to Test Virus-Derived Chemokine-Modulating Proteins as Therapeutics

    • Michelle Burgin, Jordan R. Yaron, Liqiang Zhang, Qiuyun Guo, Juliane Daggett, Jacquelyn Kilbourne et al.
    Pages 257-273

  17. A Mouse Model of Acute Liver Injury by Warm, Partial Ischemia-Reperfusion for Testing the Efficacy of Virus-Derived Therapeutics

    • Jordan R. Yaron, Liqiang Zhang, Qiuyun Guo, Hao Chen, Alexandra R. Lucas
    Pages 275-292

  18. Back Matter

    Pages 293-294
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Keywords

About this book

This detailed volume explores methods and techniques reflecting how viruses can be a beneficial force for all levels of life as well as the mammalian microbiota. Beginning with methods for the development and study of viruses, the book continues with current techniques and approaches used to develop new treatments from virus-derived vaccines to vectors and proteins, such as a range of models and methods designed to measure therapeutic efficacy of virus-derived biologics and therapeutic proteins. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Viruses as Therapeutics: Methods and Protocols is an ideal guide for researchers working to further understand how viruses can benefit lifeforms and even prevent damage from other viruses.

Editors and Affiliations

  • The Biodesign Institute, Arizona State University, Tempe, USA

    Alexandra R. Lucas

Bibliographic Information

  • Book Title: Viruses as Therapeutics

  • Book Subtitle: Methods and Protocols

  • Editors: Alexandra R. Lucas

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-1012-1

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1011-4Published: 28 October 2020

  • Softcover ISBN: 978-1-0716-1014-5Published: 28 October 2021

  • eBook ISBN: 978-1-0716-1012-1Published: 27 October 2020

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIV, 294

  • Number of Illustrations: 7 b/w illustrations, 52 illustrations in colour

  • Topics: Virology, Behavioral Therapy

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