Mouse Genetics
Methods and Protocols
Editors: Singh, Shree Ram, Hoffman, Robert M., Fernandez-funez, Pedro (Eds.)
Free Preview- Includes cutting-edge techniques
- Provides step-by-step detail essential for reproducible results
- Contains key implementation advice from the experts
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- About this book
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This fully updated edition provides selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages, and modeling human diseases. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and up-to-date, Mouse Genetics: Methods and Protocols, Second Edition delivers fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students, and postdoctoral fellows working in the various disciplines of genetics, developmental biology, mouse genetics, and modeling human diseases.
- Table of contents (15 chapters)
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Generation of Mouse Model (KI and CKO) via Easi-CRISPR
Pages 1-27
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Analysis of Gene Expression Using lacZ Reporter Mouse Lines
Pages 29-45
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Linear Density Sucrose Gradients to Study Mitoribosomal Biogenesis in Tissue-Specific Knockout Mice
Pages 47-60
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Mouse Models for Studying Hippocampal Adult Neural Stem Cell Biology
Pages 61-74
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Retina as a Model to Study In Vivo Transmission of α-Synuclein in the A53T Mouse Model of Parkinson’s Disease
Pages 75-85
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Table of contents (15 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Mouse Genetics
- Book Subtitle
- Methods and Protocols
- Editors
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- Shree Ram Singh
- Robert M. Hoffman
- Pedro Fernandez-funez
- Series Title
- Methods in Molecular Biology
- Series Volume
- 2224
- Copyright
- 2021
- Publisher
- Springer US
- Copyright Holder
- Springer Science+Business Media, LLC, part of Springer Nature
- eBook ISBN
- 978-1-0716-1008-4
- DOI
- 10.1007/978-1-0716-1008-4
- Hardcover ISBN
- 978-1-0716-1007-7
- Series ISSN
- 1064-3745
- Edition Number
- 2
- Number of Pages
- XI, 217
- Number of Illustrations
- 6 b/w illustrations, 41 illustrations in colour
- Topics
