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Brain Tumors

  • Book
  • © 2021

Overview

Editors:
  1. Giorgio Seano

    1. INSERM U1021 - CNRS UMR3347 Institut Curie Research Center, Orsay, France

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Neuromethods (NM, volume 158)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-xvi
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  2. In Vivo Models

    1. Front Matter

      Pages 1-1
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    2. Mouse Models of Diffuse Lower-Grade Gliomas of the Adult

      • Sofia Archontidi, Sandra Joppé, Yanis Khenniche, Chiara Bardella, Emmanuelle Huillard
      Pages 3-38

    3. In Vivo Medulloblastoma Modeling

      • Liliana Mirabal-Ortega, Magalie Larcher, Morgane Morabito, Chloé Foray, Bertrand Duvillié, Alain Eychène et al.
      Pages 39-58

    4. In Vivo Models of Brain Metastases

      • Christina S. Wong
      Pages 59-84

    5. Intravital Imaging of Brain Tumors

      • Cathy Pichol-Thievend, Boris Julien, Océane Anézo, Beatrice Philip, Giorgio Seano
      Pages 85-102

  3. Ex Vivo Models

    1. Front Matter

      Pages 103-103
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    2. Glioblastoma Patient-Derived Cell Lines: Generation of Nonadherent Cellular Models from Brain Tumors

      • Joris Guyon, Tiffanie Chouleur, Andreas Bikfalvi, Thomas Daubon
      Pages 105-117

    3. Organotypic Brain Cultures for Metastasis Research

      • Lucía Zhu, Manuel Valiente
      Pages 119-132

    4. Human Glioblastoma Organoids to Model Brain Tumor Heterogeneity Ex Vivo

      • W. Dean Pontius, Lisa C. Wallace, Katrina Fife, Christopher G. Hubert
      Pages 133-158

    5. In Vitro Mechanobiology of Glioma: Mimicking the Brain Blood Vessels and White Matter Tracts Invasion Paths

      • Pascale Monzo, Michele Crestani, Nils C. Gauthier
      Pages 159-196

  4. Treatments in Mice

    1. Front Matter

      Pages 197-197
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    2. Assessing Neurological Function in Brain Tumor Mouse Model

      • Xing Gao, Limeng Wu, Raquel D. Thalheimer, Jie Chen, Yao Sun, Grace Y. Lee et al.
      Pages 199-220

    3. Dynamic Immunotherapy Study in Brain Tumor-Bearing Mice

      • Luiz Henrique Medeiros Geraldo, Yunling Xu, Thomas Mathivet
      Pages 221-237

    4. Experimental and Preclinical Tools to Explore the Main Neurological Impacts of Brain Irradiation: Current Insights and Perspectives

      • Laura Mouton, Monica Ribeiro, Marc-André Mouthon, Fawzi Boumezbeur, Denis Le Bihan, Damien Ricard et al.
      Pages 239-261

  5. Clinical Imaging

    1. Front Matter

      Pages 263-263
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    2. Mechano-Biological Features in a Patient-Specific Computational Model of Glioblastoma

      • Francesco Acerbi, Abramo Agosti, Jacopo Falco, Stefano Marchesi, Ignazio G. Vetrano, Francesco DiMeco et al.
      Pages 265-287

    3. Magnetic Resonance Imaging for Quantification of Brain Vascular Perfusion

      • Line Brennhaug Nilsen, Kyrre Eeg Emblem
      Pages 289-321

    4. MRI Morphometry in Brain Tumors: Challenges and Opportunities in Expert, Radiomic, and Deep-Learning-Based Analyses

      • Marco C. Pinho, Kaustav Bera, Niha Beig, Pallavi Tiwari
      Pages 323-368

  6. Back Matter

    Pages 369-370
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Keywords

About this book

This volume explores the latest models and techniques used to study brain tumor biology. Chapters in this book are organized into four sections: in vivo models, ex vivo models, treatments in mice, and clinical imaging. Some of the topics covered in this book are in vivo preclinical models of lower-grade gliomas, medulloblastoma, and brain metastases; ex vivo methods for glioblastoma patient-derived cell lines and organotypic brain cultures for metastasis; in vivo treatments of preclinical models that assess neurological function, dynamic immunotherapy, and neurological impacts of brain irradiation; and clinical imaging and modeling, such as biomechanics and vascular perfusion. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. 


Cutting-edge and practical, Brain Tumors is a valuable resource that will help readers understand the heterogeneity of the techniques used to study the complexity of brain tumors. 


Editors and Affiliations

  • INSERM U1021 - CNRS UMR3347 Institut Curie Research Center, Orsay, France

    Giorgio Seano

Bibliographic Information

  • Book Title: Brain Tumors

  • Editors: Giorgio Seano

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-0716-0856-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-0855-5Published: 18 September 2020

  • Softcover ISBN: 978-1-0716-0858-6Published: 18 September 2021

  • eBook ISBN: 978-1-0716-0856-2Published: 17 September 2020

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XVI, 370

  • Number of Illustrations: 11 b/w illustrations, 64 illustrations in colour

  • Topics: Neurosciences, Cancer Research, Physiology

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