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Methods in Molecular Biology

Cerebral Cavernous Malformations (CCM)

Methods and Protocols

Editors: Trabalzini, Lorenza, Finetti, Federica, Retta, Saverio Francesco (Eds.)

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  • Includes cutting-edge methods and protocols
    Provides step-by-step detail essential for reproducible results
    Contains key notes and implementation advice from the experts

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About this book

This volume provides experimental approaches aimed to characterize the Cerebral Cavernous Malformations (CCM) disease and to define the cellular and molecular mechanisms underlying this pathology. Chapters are divided into four sections providing a general overview of the natural history, epidemiology, and pathogenetic mechanisms of CCM disease, describing methods currently used for diagnosis and treatment, production and analysis of distinct cellular and animal models in which CCM can be studied, and different methodological approaches to study the mechanisms underlying the CCM onset and progression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Cerebral Cavernous Malformations (CCM): Methods and Protocols  aims to ensure successful results in the further study of this complex disease and its pathophysiologic correlates.

Table of contents (36 chapters)

Table of contents (36 chapters)
  • From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease

    Pages 3-25

    Retta, Saverio Francesco (et al.)

  • Incidence, Prevalence, and Clinical Presentation of Cerebral Cavernous Malformations

    Pages 27-33

    Flemming, Kelly D.

  • Natural History, Clinical, and Surgical Management of Cavernous Malformations

    Pages 35-46

    Vercelli, Giovanni G. (et al.)

  • Molecular Genetic Screening of CCM Patients: An Overview

    Pages 49-57

    Tournier-Lasserve, Elisabeth

  • Next Generation Sequencing (NGS) Strategies for Genetic Testing of Cerebral Cavernous Malformation (CCM) Disease

    Pages 59-75

    Benedetti, Valerio (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-0716-0640-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-0716-0639-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cerebral Cavernous Malformations (CCM)
Book Subtitle
Methods and Protocols
Editors
  • Lorenza Trabalzini
  • Federica Finetti
  • Saverio Francesco Retta
Series Title
Methods in Molecular Biology
Series Volume
2152
Copyright
2020
Publisher
Springer US
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-0716-0640-7
DOI
10.1007/978-1-0716-0640-7
Hardcover ISBN
978-1-0716-0639-1
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XV, 496
Number of Illustrations
24 b/w illustrations, 62 illustrations in colour
Topics

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