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Physiology in Health and Disease
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Role of the Choroid Plexus in Health and Disease

Editors: Praetorius, Jeppe, Blazer-Yost, Bonnie, Damkier, Helle (Eds.)

  • Broadens readers’ understanding of the clinical importance of the choroid plexus as the main source of cerebrospinal fluid 
  • Shares insights into drug development strategies targeting the blood / cerebrospinal fluid barrier using choroid plexus epithelial cells
  • Emphasizes the correlation between the production and composition of CSF and the maintenance of normal brain function     
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  • ISBN 978-1-0716-0536-3
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Hardcover $179.99
price for USA in USD
  • ISBN 978-1-0716-0535-6
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About this book

This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. 

Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia.

Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.

About the authors

Jeppe Praetorius

Department of Biomedicine

Aarhus University

Aarhus

Denmark


Bonnie Blazer-Yost

Department of Biology

Indiana University – Purdue University Indianapolis

Indianapolis

Indiana

USA


Helle Damkier

Department of Biomedicine

Aarhus University

Aarhus

Denmark


Table of contents (12 chapters)

Table of contents (12 chapters)
  • Structure of the Mammalian Choroid Plexus

    Pages 1-33

    Damkier, Helle (et al.)

  • Blending Established and New Perspectives on Choroid Plexus-CSF Dynamics

    Pages 35-81

    Johanson, Conrad E. (et al.)

  • A Frog Model for CSF Secretion

    Pages 83-97

    Loo, Donald D. F. (et al.)

  • Cotransport of Water in the Choroid Plexus Epithelium: From Amphibians to Mammals

    Pages 99-124

    Steffensen, Annette B. (et al.)

  • The Significance of the Choroid Plexus for Cerebral Iron Homeostasis

    Pages 125-148

    Routhe, Lisa Juul (et al.)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-1-0716-0536-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-1-0716-0535-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Role of the Choroid Plexus in Health and Disease
Editors
  • Jeppe Praetorius
  • Bonnie Blazer-Yost
  • Helle Damkier
Series Title
Physiology in Health and Disease
Copyright
2020
Publisher
Springer US
Copyright Holder
The American Physiological Society
eBook ISBN
978-1-0716-0536-3
DOI
10.1007/978-1-0716-0536-3
Hardcover ISBN
978-1-0716-0535-6
Series ISSN
2625-252X
Edition Number
1
Number of Pages
VI, 287
Number of Illustrations
19 b/w illustrations, 46 illustrations in colour
Topics

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