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Methods in Molecular Biology
cover

Targeting Enzymes for Pharmaceutical Development

Methods and Protocols

Editors: Labrou, Nikolaos (Ed.)

  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts
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  • ISBN 978-1-07-160163-1
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  • ISBN 978-1-07-160162-4
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About this book

This volume explores detailed methods and experimental protocols evaluating the effect of a compound or a mixture of compounds on the action of enzymes that are significant targets in pharmaceuticals. Consisting of three sections, the book delves into recent biocomputing and bioinformatics protocols, state-of-the art modern biophysical, electrophoretic, and chromatographic methods and high-throughput screening approaches, as well as detailed protocols and examples of the inhibition analysis and evaluation of selected enzymes. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 
Authoritative and cutting-edge, Targeting Enzymes for Pharmaceutical Development: Methods and Protocols serves as a vital reference for academics and industry professionals working on expanding our understanding of the wide range of important enzyme targets.

Table of contents (19 chapters)

Table of contents (19 chapters)
  • In Silico Laboratory: Tools for Similarity-Based Drug Discovery

    Pages 1-28

    Lešnik, Samo (et al.)

  • The In Silico Fischer Lock-and-Key Model: The Combined Use of Molecular Descriptors and Docking Poses for the Repurposing of Old Drugs

    Pages 29-39

    Tutone, Marco (et al.)

  • Determination of Half-Maximal Inhibitory Concentration of an Enzyme Inhibitor

    Pages 41-46

    Georgakis, Nikolaos (et al.)

  • Applications of Differential Scanning Fluorometry and Related Technologies in Characterization of Protein–Ligand Interactions

    Pages 47-68

    Baljinnyam, Bolormaa (et al.)

  • High-Throughput Differential Scanning Fluorimetry of GFP-Tagged Proteins

    Pages 69-85

    Sorenson, Alanna E. (et al.)

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-07-160163-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-1-07-160162-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Targeting Enzymes for Pharmaceutical Development
Book Subtitle
Methods and Protocols
Editors
  • Nikolaos Labrou
Series Title
Methods in Molecular Biology
Series Volume
2089
Copyright
2020
Publisher
Springer US
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-07-160163-1
DOI
10.1007/978-1-0716-0163-1
Hardcover ISBN
978-1-07-160162-4
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 290
Number of Illustrations
42 b/w illustrations, 71 illustrations in colour
Topics

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