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Developments in Nephrology

Diuretics: Basic, Pharmacological, and Clinical Aspects

Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986

Editors: Andreucci, V.E., Canton, Antonia Dal (Eds.)

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About this book

The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car­ bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car­ bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.

Table of contents (148 chapters)

Table of contents (148 chapters)
  • Diuretics in the Salernitan Medicine

    Pages 3-8

    Canton, A. (et al.)

  • Ion Transport and Metabolism in Renal Cells

    Pages 11-20

    Mandel, L. J.

  • Hydrogen Secretion Regulated by Intracellular Membrane Potential: A Hypothesis on the Regulation of Renal Acidification

    Pages 21-26

    Oberleithner, H. (et al.)

  • Isolation and Purification of the Amiloride-Sensitive Na+ Channel from Renal Epithelia

    Pages 27-32

    Benos, Dale J. (et al.)

  • Blockers of Active Transport in the Thick Ascending Limb of the Loop of Henle

    Pages 33-38

    Greger, R. (et al.)

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-1-4613-2067-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.99
price for USA in USD
  • ISBN 978-0-89838-885-5
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • ISBN 978-1-4612-9227-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Diuretics: Basic, Pharmacological, and Clinical Aspects
Book Subtitle
Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986
Editors
  • V.E. Andreucci
  • Antonia Dal Canton
Series Title
Developments in Nephrology
Series Volume
18
Copyright
1987
Publisher
Springer US
Copyright Holder
Martinus Nijhoff Publishing, Boston
eBook ISBN
978-1-4613-2067-8
DOI
10.1007/978-1-4613-2067-8
Hardcover ISBN
978-0-89838-885-5
Softcover ISBN
978-1-4612-9227-2
Edition Number
1
Number of Pages
LVI, 576
Topics

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