Developments in Oncology

Minimal Residual Disease in Acute Leukemia 1986

Editors: Hagenbeek, A., Löwenberg, B. (Eds.)

Free Preview

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-94-009-4273-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.99
price for USA in USD
  • ISBN 978-0-89838-799-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-94-010-8398-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Relapse of leukemia following successful remission-induction therapy remains a major obstacle in the treatment of patients with acute leukemia. Leukemia recurs most frequently in patients with acute myeloblastic leukemia (AML) and high risk acute lymphoblastic leukemia (ALL) following chemotherapy and less often in patients with low risk ALL and particularly in patient groups> submitted to allogeneic marrow transplantation. ' It is likely that the great majority of these recurrences originate from residual leukemic cells that survive initial remission-induction chemotherapy. Today, several research groups throughout the world place emphasis on studies concerned with the detection and treatment of 'minimal residual disease' (MRD). These investigations are conducted with the common objective to tackle the remaining cells. 'Minimal Residual Disease in Acute Leukemia: 1986' summarizes the fast advancements in this area. Several disciplines are concerned with the analysis of leukemic cells. The perspectives of cytogenetic and molecular genetic approaches for applica­ tion in the detection of MRD are reviewed. In this respect, modern cyto­ genetics provide highly specific tumor markers. The resolution of cyto­ genetic methods can be particularly improved when combined with other techniques which select relevant subpopulations of cells. Characterization of oncogenes and gene rearrangements, including those of immunoglobulin and T-cell receptor genes, and the measurement of gene products, have been established. Techniques based on these approaches offer interesting tools for the detection of MRD. New possibilities of employing monoclonal anti­ bodies are also presented.

Table of contents (36 chapters)

Table of contents (36 chapters)
  • New Possibilities for Cytogenetic Analysis of Leukemic Cells

    Hagemeijer, A. (et al.)

    Pages 1-11

  • Breakpoint Analysis in CML: Potentials for Detection of Minimal Residual Disease

    Grosveld, G. C. (et al.)

    Pages 12-22

  • The Mammalian ETS Genes: Two Unique Chromosomal Locations in Cat, Mice and Man and Novel Translocated Position in Human Leukemias

    Papas, T. S. (et al.)

    Pages 23-42

  • Activated RAS Oncogenes in Acute Leukemia

    Bos, J. L. (et al.)

    Pages 43-50

  • DNA Rearrangements as Unique Markers of Clonal Evolution, Recurrence and Translocation

    Wright, J. J., M.D., Ph.D. (et al.)

    Pages 51-57

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-94-009-4273-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.99
price for USA in USD
  • ISBN 978-0-89838-799-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-94-010-8398-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Minimal Residual Disease in Acute Leukemia 1986
Editors
  • A. Hagenbeek
  • B. Löwenberg
Series Title
Developments in Oncology
Series Volume
45
Copyright
1986
Publisher
Springer Netherlands
Copyright Holder
Martinus Nijhoff Publishers, Dordrecht
eBook ISBN
978-94-009-4273-8
DOI
10.1007/978-94-009-4273-8
Hardcover ISBN
978-0-89838-799-5
Softcover ISBN
978-94-010-8398-0
Edition Number
1
Number of Pages
XIV, 393
Topics