Developments in Cardiovascular Medicine

Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions

Editors: Godfraind, T., Herman, A.G., Wellens, D. (Eds.)

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2 The free internal Ca+ concentration in human red cells is set according to the leak­ 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca­ 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady­ 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con­ 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec­ 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra­ tion is ;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower).

Table of contents (29 chapters)

Table of contents (29 chapters)

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-94-009-6033-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA in USD
  • ISBN 978-0-89838-658-5
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $79.99
price for USA in USD
  • ISBN 978-94-009-6035-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions
Editors
  • T. Godfraind
  • A.G. Herman
  • D. Wellens
Series Title
Developments in Cardiovascular Medicine
Series Volume
40
Copyright
1984
Publisher
Springer Netherlands
Copyright Holder
Martinus Nijhoff Publishers, The Hague
eBook ISBN
978-94-009-6033-6
DOI
10.1007/978-94-009-6033-6
Hardcover ISBN
978-0-89838-658-5
Softcover ISBN
978-94-009-6035-0
Series ISSN
0166-9842
Edition Number
1
Number of Pages
325
Topics