Developments in Oncology

Organ Directed Toxicities of Anticancer Drugs

Proceedings of the First International Symposium on the Organ Directed Toxicities of the Anticancer Drugs Burlington, Vermont, USA-June 4–6, 1987

Editors: Hacker, Miles, Lazo, John S., Tritton, Thomas R. (Eds.)

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About this book

The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif­ ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in­ tervention. Much of this toxicity, such as damage to the bone marrow, gastroin­ testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively dividing cells. These types of toxicities, while serious, are usually manageable and reversible and are, therefore, not often considered to be dose limiting. Unfortunately, several of the most important anticancer drugs also damage tissues in which the growth fraction is relatively small. Such toxicities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre­ dicted toxicities are usually irreversible or only partially reversible upon cessation of drug administration. Because of this, the unpredicted toxicities are referred to as dose limiting. They represent a significant barrier to the ultimate efficacy of several of our most important anticancer drugs.

Table of contents (20 chapters)

Table of contents (20 chapters)

Buy this book

eBook $129.00
price for USA in USD
  • ISBN 978-1-4613-2023-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-89838-356-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $169.99
price for USA in USD
  • ISBN 978-1-4612-9205-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Organ Directed Toxicities of Anticancer Drugs
Book Subtitle
Proceedings of the First International Symposium on the Organ Directed Toxicities of the Anticancer Drugs Burlington, Vermont, USA-June 4–6, 1987
Editors
  • Miles Hacker
  • John S. Lazo
  • Thomas R. Tritton
Series Title
Developments in Oncology
Series Volume
53
Copyright
1988
Publisher
Springer US
Copyright Holder
Martinus Nijhoff Publishing, Boston
eBook ISBN
978-1-4613-2023-4
DOI
10.1007/978-1-4613-2023-4
Hardcover ISBN
978-0-89838-356-0
Softcover ISBN
978-1-4612-9205-0
Edition Number
1
Number of Pages
XII, 254
Topics