Methods in Molecular Medicine

Hemoglobin Disorders

Molecular Methods and Protocols

Editors: Nagel, Ronald L. (Ed.)

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eBook $139.00
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  • ISBN 978-1-59259-373-6
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Hardcover $179.00
price for USA in USD
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Softcover $179.00
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About this book

The recent announcement that sickle-cell anemia and thalassemia have been corrected by the transplantation of stem cells bodes well for the future of gene therapy in hemoglobinopathies. In Hemoglobin Disorders: Molecular Methods and Protocols, Ronald Nagel, MD, has assembled a collection of readily reproducible techniques essential to the continued advance of our molecular understanding of these diseases. The book's richly experienced authors detail methods utilizing a wide variety of the latest analytical techniques, including X-ray crystallography, high performance liquid chromatography, electrophoresis, and nuclear magnetic resonance. Additional methods are offered for prenatal diagnostic analysis, the DNA diagnosis of hemoglobin mutations, hemoglobin fluorescence, and the semisynthesis of hemoglobin. Each protocol includes an introduction explaining the basic science, step-by-step instructions for its successful execution, notes on pitfalls to avoid, and tips on how to employ it effectively with novel systems and conditions.
State-of-the-art and highly practical, Hemoglobin Disorders: Molecular Methods and Protocols reviews all the basic topics and techniques in this critically important field, and offers today's most comprehensive set of proven protocols for successful experimental and clinical work on hemoglobin diseases.

Reviews

"...the book is a very good practical volume for those interested in further clinical and experimental studies of hemoglobin disorders." - Biomedical Chromatography

Table of contents (16 chapters)

  • X-ray Crystallography of Hemoglobins

    Safo, Martin K. (et al.)

    Pages 1-19

  • Analysis of Hemoglobins and Globin Chains by High-Performance Liquid Chromatography

    Wajcman, Henri

    Pages 21-29

  • Purification and Molecular Analysis of Hemoglobin by High-Performance Liquid Chromatograpy

    Manjula, Belur N. (et al.)

    Pages 31-47

  • Oxygen Equilibrium Measurements of Human Red Blood Cells

    Kister, Jean (et al.)

    Pages 49-64

  • Measurement of Rate Constants for Reactions of O2, CO, and NO with Hemoglobin

    Olson, John S. (et al.)

    Pages 65-91

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-59259-373-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA in USD
  • ISBN 978-0-89603-962-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA in USD
  • ISBN 978-1-61737-278-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Hemoglobin Disorders
Book Subtitle
Molecular Methods and Protocols
Editors
  • Ronald L. Nagel
Series Title
Methods in Molecular Medicine
Series Volume
82
Copyright
2003
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-373-6
DOI
10.1385/1592593739
Hardcover ISBN
978-0-89603-962-9
Softcover ISBN
978-1-61737-278-0
Series ISSN
1543-1894
Edition Number
1
Number of Pages
XX, 300
Topics