Handbook of Copper Pharmacology and Toxicology

Editors: Massaro, Edward J. (Ed.)

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About this book

Although copper is an essential trace element necessary for the survival of organisms ranging from bacteria to mammals, it is also highly toxic and must be absorbed by the body in precisely orchestrated biological processes. In Handbook of Copper Pharmacology and Toxicology, Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general, and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases-Menkes and Wilson's diseases and occipital horn syndrome-as well as the role of copper in Parkinson's disease, prion disease, familial amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The elucidation of the precise mechanisms of copper trafficking, metabolism, and homeostasis will be of considerable importance in understanding the pathophysiology and treatment of such diseases.
Comprehensive and timely, the Handbook of Copper Pharmacology and Toxicology authoritatively provides researchers with all the up-to-date information needed to work productively in copper biology today.

Reviews

"...biochemical and molecular researchers from around the globe have produced 35 chapters documenting the present state of knowledge in selected areas of copper pharmacology and toxicology. the state-of-the-art data provided will no doubt stimulate challenging research with this essential trace element required by organism ranging from bacteria to mammals." - Veterinary and Human Toxicology

"The book has excellent introductory chapters, and summarizes much recent research at the genetic and cellular levels." - Newsletter of the British Toxicological Society

"Dr. Massaro must be congratulated for editing this comprehensive book on copper. There are so many outstanding chapters in this compendium that highlighting any one of them should not detract from the others...this book is a treasure trove of references. The price of the book, though modest for this compendium would be justified for the Preface and the first chapter alone. This book is highly recommended. At the present time it has no equal." -International Journal of Toxicology

Table of contents (35 chapters)

Table of contents (35 chapters)
  • Biochemistry and Molecular Biology of Copper in Mammals

    Linder, Maria C.

    Pages 3-32

  • Biochemistry of the Wilson’s Disease Protein

    Lutsenko, Svetlana (et al.)

    Pages 35-51

  • Biologically Relevant Properties of Copper-Containing Proteins Analyzed by Means of Semiquantitative and Quantitative Theoretical Descriptors

    Rienzo, Francesca (et al.)

    Pages 53-80

  • Molecular Modeling and Dynamics of Copper Proteins

    Falconi, Mattia (et al.)

    Pages 81-101

  • The Prion Protein and Copper

    Brown, Lesley R. (et al.)

    Pages 103-113

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-59259-288-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-0-89603-943-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-61737-266-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Handbook of Copper Pharmacology and Toxicology
Editors
  • Edward J. Massaro
Copyright
2002
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-288-3
DOI
10.1007/978-1-59259-288-3
Hardcover ISBN
978-0-89603-943-8
Softcover ISBN
978-1-61737-266-7
Edition Number
1
Number of Pages
XVI, 608
Number of Illustrations
114 b/w illustrations
Topics