Cancer Drug Discovery and Development

Tumor Suppressor Genes in Human Cancer

Editors: Fisher, David E. (Ed.)

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About this book

While the war against cancer has seen great advances in our understanding of cell proliferation and its regulation at the molecular level, the translation of this knowledge into effective therapies has lagged well behind. In Tumor Suppressor Genes in Human Cancer, David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Additional coverage is accorded animal models, viral oncoproteins as probes, and cancer metastasis. An extensive chapter on cancer drug discovery is provided to help integrate the new molecular oncology with technologies which fuel the pragmatic search for improved cancer therapeutics.
Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

Reviews

"...brings together a panel of experts in the field of cancer biology, with almost half of the authors from Harvard Medical School. ...describes he role of tumor suppressor genes in human cancer. It details a current view of these important genes and highlights clinically relevant aspects of the strides made in the field of tumor suppressor biology. ...The book is well organized with most chapters having figures and tables to clarify the points made in the text. It is well referenced....This book provides readable, yet thorough, coverage of the field of tumor suppressor biology." -Doody's Health Sciences Book Review Journal

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Animal Models for Tumor Suppressor Genes

    Pages 3-28

    Kreidberg, Jordan A., MD, PhD (et al.)

  • Viral Oncoproteins as Probes for Tumor Suppressor Function

    Pages 29-48

    Chellappan, Srikumar P., PhD

  • Tumor Suppressors in Metastasis

    Pages 49-77

    Ouatas, Taoufik, PhD (et al.)

  • Apoptosis

    Pages 79-101

    Du, Jinyan (et al.)

  • Drug Discovery in Oncology

    Pages 103-128

    Matter, Alex, MD

Buy this book

eBook n/a
  • ISBN 978-1-59259-230-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-0-89603-807-3
  • Free shipping for individuals worldwide
Softcover n/a
  • ISBN 978-1-61737-198-1
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Suppressor Genes in Human Cancer
Editors
  • David E. Fisher
Series Title
Cancer Drug Discovery and Development
Copyright
2001
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-230-2
DOI
10.1007/978-1-59259-230-2
Hardcover ISBN
978-0-89603-807-3
Softcover ISBN
978-1-61737-198-1
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XII, 386
Topics