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Contemporary Neuroscience

Mitochondrial Inhibitors and Neurodegenerative Disorders

Editors: Sanberg, Paul R., Nishino, Hitoo, Borlongan, Cesario V. (Eds.)

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eBook $129.00
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  • ISBN 978-1-59259-692-8
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Hardcover $219.99
price for USA in USD
  • ISBN 978-0-89603-805-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
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  • ISBN 978-1-4684-9821-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In Mitochondrial Inhibitors and Neurodegenerative Disorders, respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers-many pioneers in the field-detail the symptomatology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The book focuses on 3-nitropropionic acid (3-NP) and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington's disease, and demonstrates that mitochondrial inhibitors play an important role in the etiology of central nervous system disorders. In addition, recent therapeutic modalities aimed at rescuing the central nervous system from abnormal functioning by mitochondria are discussed.
With its timely, in-depth review, Mitochondrial Inhibitors and Neurodegenerative Disorders offers today's advanced investigators powerful insights into how mitochondrial toxins precipitate and exacerbate neurodegenerative disorders, and details important new treatment strategies that can halt or reverse disease progression.

Reviews

"...is a concise summary of the present state of research in the area of mitochondrial toxins and their role in animal models of neurodegenerative disease."-J Neuropsychiatry Clin Neurosci

Table of contents (20 chapters)

Table of contents (20 chapters)
  • Clinical Manifestations and Mechanisms of Action of Environmental Mitochondrial Toxins

    Pages 3-19

    Sabri, Mohammad I. (et al.)

  • History of 3-Nitropropionic Acid

    Pages 21-33

    Hamilton, Bradley F. (et al.)

  • The Neurochemistry of 3-Nitropropionic Acid

    Pages 35-49

    Reynolds, Norman C., Jr. (et al.)

  • In Vitro Studies of 3-Nitropropionic Acid

    Pages 53-72

    Zeevalk, Gail D.

  • Cognitive and Motor Deficits Produced by Acute and Chronic Administration of 3-Nitropropionic Acid in Rats

    Pages 73-92

    Dunbar, Gary L. (et al.)

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-1-59259-692-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-89603-805-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-1-4684-9821-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mitochondrial Inhibitors and Neurodegenerative Disorders
Editors
  • Paul R. Sanberg
  • Hitoo Nishino
  • Cesario V. Borlongan
Series Title
Contemporary Neuroscience
Copyright
2000
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-692-8
DOI
10.1007/978-1-59259-692-8
Hardcover ISBN
978-0-89603-805-9
Softcover ISBN
978-1-4684-9821-9
Edition Number
1
Number of Pages
XVIII, 314
Number of Illustrations
81 b/w illustrations
Topics