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  • Book
  • © 2001

Parkinson's Disease

Methods and Protocols

Editors:

  1. M. Maral Mouradian

    1. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda

    View editor publications

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Part of the book series: Methods in Molecular Medicine (MIMM, volume 62)

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Table of contents (21 protocols)

  1. Front Matter

    Pages i-xi
    PDF

  2. Genetics

    1. Front Matter

      Pages 1-1
      PDF

    2. Point Mutations in the α-Synuclein Gene

      • Abbas Parsian, Joel S. Perlmutter
      Pages 3-11

    3. Autosomal Recessive Juvenile Parkinsonism (AR-JP): Genetic Diagnosis

      • Hiroto Matsumine, Nobutaka Hattori, Yoshikuni Mizuno
      Pages 13-29

  3. Molecular Pathogenetic Studies

    1. Front Matter

      Pages 31-31
      PDF

    2. Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as α-Synucleinopathies

      • Michel Goedert, Ross Jakes, R. Anthony Crowther, Maria Grazia Spillantini
      Pages 33-59

    3. α-Synuclein/Amyloid Interactions

      • Poul Henning Jensen
      Pages 61-65

    5. Molecular Biology of Dopamine-Induced Apoptosis

      • Ilan Ziv, Anat Shirvan, Daniel Offen, Ari Barzilai, Eldad Melamed
      Pages 73-87

    6. Animal Models of Induced Apoptotic Death in the Substantia Nigra

      • Tinmarla F. Oo, Rober E. Burke
      Pages 89-99

    8. The Role of Nitric Oxide in Parkinson's Disease

      • Serge Przedborski, Ted M. Dawson
      Pages 113-136

    9. Oxidative Stress Indices in Parkinson's Disease

      • Moussa B. H. Youdim, Noam Drigues, Silvia Mandel
      Pages 137-153

  4. Molecular Aspects of Basal Ganglia Function

    1. Front Matter

      Pages 155-155
      PDF

    2. Quantification of Tyrosine Hydroxylase mRNA

      • Hiroshi Ichinose, Tamae Ohye, Takahiro Suzuki, Hidehito Inagaki, Toshiharu Nagatsu
      Pages 157-166

    4. Dopamine Transporter and Vesicular Monoamine Transporter Knockout Mice

      • Gary W. Miller, Yan-Min Wang, Raul R. Gainetdinov, Marc G. Caron
      Pages 179-190

    5. Transcription Mechanisms for Dopamine Receptor Genes

      • Sang-Hyeon Lee, M. Maral Mouradian
      Pages 191-215

    6. Detection of DNA/Protein Interactions in Dopamine Receptor Genes

      • Sang-Hyeon Lee, M. Maral Mouradian
      Pages 217-227

    7. In Situ Hybridization on Brain Tissue

      • Claas-Hinrich Lammers, Yoshinobu Hara, M. Maral Mouradian
      Pages 229-246
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About this book

Parkinson’s disease is a progressive neurodegenerative disorder charact- ized clinically by tremor, rigidity, slow movements, and postural instability. Pathologically, dopaminergic neurons of the substantia nigra bear the brunt of the degeneration, though other neuronal groups can be affected as well. Although Parkinson’s disease is the only neurodegenerative disorder for which effective therapies are available, these treatment options are only symptomatic, do not influence the underlying degenerative process, and are associated with a high incidence of complications, particularly with their long-term use. The progressive nature of the disease and the limitations of its palliative therapies result in significant functional impairment. The chronic disability and the increased prevalence of the disease with the prolongation of life expectancy in developed countries make the social and economic impact of this disease quite high. For- nately, systematic basic and clinical research in this disease has yielded major new advances that render patients’ hopes for a cure considerably closer to reality. The application of molecular biologic methodologies in the study of Parkinson’s disease has begun to have a major impact only in recent years. Con- quently, the utility of these technologies is largely in the research arena, although their clinical applications are now being realized.
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Reviews

"The most unique feature of this book is the detail in which the molecular methods are described. Each author has provided detailed information about his or her methodology, including equipment and reagents used. The book is divided into four large sections: genetics, molecular pathogenetic studies, molecular studies of the basal ganglia, and molecular therapies. . .This is a fairly unique book. . .The level of methodological detail is greater than what is provided in a typical research publication. Active researchers will find it a valuable resource when designing experiments."-Doody's Health Sciences Book Review Journal

"...provides extensive coverage of the different techniques employed by molecular geneticists and neurobiologists for studying the pathogenesis of PD....Parkinson's Disease: Methods and Protocols is well organized and provides a valuable resource for graduate students and postdoctoral scientists....The notes at the end of each chapter are particularly beneficial because they are based on the practical experience of experts in the field who have developed the models and methods....covers a wide spectrum of ongoing research in the PD field and provides insight into cross-disciplinary approaches that will facilitate finding a cure for PD." - Journal of Molecular Neuroscience
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Editors and Affiliations

  • National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda

    M. Maral Mouradian

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Bibliographic Information

  • Book Title: Parkinson's Disease

  • Book Subtitle: Methods and Protocols

  • Editors: M. Maral Mouradian

  • Series Title: Methods in Molecular Medicine

  • DOI: https://doi.org/10.1385/1592591426

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2001

  • Hardcover ISBN: 978-0-89603-761-8Published: 20 April 2001

  • Softcover ISBN: 978-1-61737-175-2Published: 12 August 2011

  • eBook ISBN: 978-1-59259-142-8Published: 02 February 2008

  • Series ISSN: 1543-1894

  • Series E-ISSN: 1940-6037

  • Edition Number: 1

  • Number of Pages: XI, 317

  • Topics: Neurology

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Buy it now

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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