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Methods in Molecular Medicine

Parkinson's Disease

Methods and Protocols

Editors: Mouradian, M. Maral (Ed.)

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About this book

The use of molecular technologies to study Parkinson's disease in the laboratory is beginning to have a major impact in clinical medicine. In Parkinson's Disease: Methods and Protocols, internationally recognized biomedical investigators describe in detail the major techniques employed in molecular and cellular studies of Parkinson's disease and basal ganglia function, adding along the way considerable background information about the rationale and utility of these methods, as well as about fundamental issues in Parkinson's disease. Widely varied methods are covered, including genetic analyses, molecular pathogenetic investigations of dopaminergic neuronal degeneration, biochemical studies of nigrostriatal neural circuitry, and molecular therapies, such as gene therapy and neural stem cells.

Comprehensive and timely, Parkinson's Disease: Methods and Protocols offers scientists and clinicians interested in Parkinson's and related neurodegenerative disorders the major cutting-edge methods-in a readily reproducible format-needed to effectively exploit the potential of cell and molecular biology for elucidating disease mechanisms and for speeding the emergence of novel and more effective therapeutics.

Reviews

"The most unique feature of this book is the detail in which the molecular methods are described. Each author has provided detailed information about his or her methodology, including equipment and reagents used. The book is divided into four large sections: genetics, molecular pathogenetic studies, molecular studies of the basal ganglia, and molecular therapies. . .This is a fairly unique book. . .The level of methodological detail is greater than what is provided in a typical research publication. Active researchers will find it a valuable resource when designing experiments."-Doody's Health Sciences Book Review Journal

"...provides extensive coverage of the different techniques employed by molecular geneticists and neurobiologists for studying the pathogenesis of PD....Parkinson's Disease: Methods and Protocols is well organized and provides a valuable resource for graduate students and postdoctoral scientists....The notes at the end of each chapter are particularly beneficial because they are based on the practical experience of experts in the field who have developed the models and methods....covers a wide spectrum of ongoing research in the PD field and provides insight into cross-disciplinary approaches that will facilitate finding a cure for PD." - Journal of Molecular Neuroscience

Table of contents (21 chapters)

Table of contents (21 chapters)
  • Point Mutations in the α-Synuclein Gene

    Pages 3-11

    Parsian, Abbas (et al.)

  • Autosomal Recessive Juvenile Parkinsonism (AR-JP): Genetic Diagnosis

    Pages 13-29

    Matsumine, Hiroto (et al.)

  • Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as α-Synucleinopathies

    Pages 33-59

    Goedert, Michel (et al.)

  • α-Synuclein/Amyloid Interactions

    Pages 61-65

    Henning Jensen, Poul

  • Functional Defect Conferred by the Parkinson's Disease-Causing α-Synuclein (Ala30Pro) Mutation

    Pages 67-72

    Henning Jensen, Poul

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-1-59259-142-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
Softcover $179.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Parkinson's Disease
Book Subtitle
Methods and Protocols
Editors
  • M. Maral Mouradian
Series Title
Methods in Molecular Medicine
Series Volume
62
Copyright
2001
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-142-8
DOI
10.1385/1592591426
Hardcover ISBN
978-0-89603-761-8
Softcover ISBN
978-1-61737-175-2
Series ISSN
1543-1894
Edition Number
1
Number of Pages
XI, 317
Topics

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