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Methods in Molecular Medicine

Nonviral Vectors for Gene Therapy

Methods and Protocols

Editors: Findeis, Mark A. (Ed.)

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About this book

Nonviral gene therapy-an emerging field with great clinical promise-avoids many problems associated with viral gene therapy and offers the possibility of superior clinical effectiveness. In Nonviral Vectors for Gene Therapy: Methods and Protocols, Mark A. Findeis has assembled a panel of active researchers to present their best methods not only for preparing, handling, and characterizing gene delivery agents, but also for gene delivery. To help those preparing and characterizing gene transfer agents, the contributors examine a broad range of compounds that bind with DNA to form the compact complexes that facilitate cellular delivery-among them peptide conjugates, synthetic polymers, and lipids. They also outline specific approaches to gene transfer in vivo, including direct delivery by intratumoral injection and indirect delivery by cell-specific targeting of DNA complexes, and discuss in detail many spectroscopic techniques for characterizing nonviral gene delivery agents. Opportunities for the development and application of these novel vectors in the research lab and eventually, in the clinic, are highlighted.
Comprehensive and state-of-the-art, Nonviral Vectors for Gene Therapy: Methods and Protocols illuminates for today's investigators the powerful new approaches to the creation of nonviral materials, as well as their efficacious use in delivering therapeutic genes to patients across the spectrum of human disease.

Reviews

"The book begins with a series of chapters covering specific protocols concerning gene delivery agents. These are followed by several review chapters that provide additional information on preparing and characterizing gene transfer agents. Particular focus is given to spectroscopic techniques. The final chapter provides a review of renal gene therapy. Chapters are well organized and often accompanied by helpful figures. Each chapter includes a list of references, an an index is provided. Contributors are from research facilities throughout the world. This book is highly recommended for collections serving researchers in the area of gene therapy." - E-Streams

Table of contents (23 chapters)

Table of contents (23 chapters)
  • Synthesis of Polyampholyte Comb-Type Copolymers Consisting of a Poly(L-lysine) Backbone and Hyaluronic Acid Side Chains for DNA Carrier

    Pages 1-9

    Maruyama, Atsushi (et al.)

  • Cationic α-Helical Peptides for Gene Delivery into Cells

    Pages 11-21

    Niidome, Takuro (et al.)

  • Supramolecular Self-Assembly of Poly(ethylene glycol)-Block-Poly (L-lysine) Dendrimer with Plasmid DNA

    Pages 23-33

    Choi, Joon Sig (et al.)

  • Water-Soluble Cationic Methacrylate Polymers for Nonviral Gene Delivery

    Pages 35-60

    Bos, Gert W. (et al.)

  • Stabilization of Polycation-DNA Complexes by Surface Modification with Hydrophilic Polymers

    Pages 61-78

    Oupicky, David (et al.)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-1-59259-139-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-0-89603-712-0
  • Free shipping for individuals worldwide. COVID shipping restrictions apply.
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-61737-145-5
  • Free shipping for individuals worldwide. COVID shipping restrictions apply.
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Nonviral Vectors for Gene Therapy
Book Subtitle
Methods and Protocols
Editors
  • Mark A. Findeis
Series Title
Methods in Molecular Medicine
Series Volume
65
Copyright
2001
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-139-8
DOI
10.1385/1592591396
Hardcover ISBN
978-0-89603-712-0
Softcover ISBN
978-1-61737-145-5
Series ISSN
1543-1894
Edition Number
1
Number of Pages
XI, 399
Topics

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