Methods in Molecular Biology

Posttranslational Modification of Proteins

Tools for Functional Proteomics

Editors: Kannicht, Christoph (Ed.)

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About this book

The majority of all proteins undergo posttranslational modifications that significantly alter their physical and chemical properties, including their folding and conformation distribution, their stability, and, consequently, their activity and function. In Posttranslational Modifications of Proteins: Tools for Functional Proteomics, Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the most important of these modifications, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins. Among the methods presented are those for analyzing the assignment of disulfide bond sites in proteins, protein N-glycosylation and protein O-glycosylation, and oligosaccharides present at specific single glycosylation sites in a protein. Additional powerful techniques facilitate the analysis of glycosylphosphatidylinositols, lipid modifications, protein phosphorylation and sulfation, protein methylation and acetylation, a-amidation, g-glutamate, isoaspartate, and lysine hydroxylation.
Comprehensive and state-of-the-art, Posttranslational Modifications of Proteins: Tools for Functional Proteomics serves as a highly practical guide for all investigators of protein structure-function relationships not only in chemical and pharmaceutical research, but also throughout the rapidly growing field of functional proteomics.

Reviews

"As indicated by the editor, this book will be useful to researchers involved in elucidating protein structure and function as well as those working to design proteins with specific function...this book offers detailed analytical protocols for identifying and characterizing most types of co- and post- translational modifications" - Pharmaceutical Research

"This book provides researchers in the biological sciences with the most updated methods to investigate co- and/or post-translational modifications of proteins...Either trained professionals and students working in the field of proteomics can take benefit for their research." - Proteomics

"It will definitely find appreciative readers among a wide audience of glycobiologists, biochemists, molecular biologists, biotechnologists, and researchers specializing in pharmacology and molecular medicine. This book will be a very useful tool for teachers and students of universities and institutes." -Biochemistry

Buy this book

eBook n/a
  • ISBN 978-1-59259-181-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-0-89603-678-9
  • Free shipping for individuals worldwide
Softcover n/a
  • ISBN 978-1-4899-3864-0
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Posttranslational Modification of Proteins
Book Subtitle
Tools for Functional Proteomics
Editors
  • Christoph Kannicht
Series Title
Methods in Molecular Biology
Series Volume
194
Copyright
2002
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-181-7
DOI
10.1385/1592591817
Hardcover ISBN
978-0-89603-678-9
Softcover ISBN
978-1-4899-3864-0
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 322
Number of Illustrations
19 b/w illustrations
Topics