Overview
- Editors:
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John M. Walker
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Stephen M. Keyse
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ICRF Laboratories, University of Dundee, UK
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Table of contents (28 protocols)
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Detection and Assay of Stress-Induced Damage
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- Prabodh K. Sehajpal, Harry M. Lander
Pages 3-14
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- Rodney L. Levine, Nancy Wehr, Joy A. Williams, Earl R. Stadtman, Emily Shacter
Pages 15-24
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- Koji Uchida, Earl R. Stadtman
Pages 25-34
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- Cecile M. Krejsa, Gary L. Schieven
Pages 35-47
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- Thomas Reinheckel, Tilman Grune, Kelvin J. A. Davies
Pages 49-60
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The Activation of Signal Transduction by Cellular Stress
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- D. Grahame Hardie, Ian P. Salt, Stephen P. Davies
Pages 63-74
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- Yamini Achari, Susan P. Lees-Miller
Pages 85-97
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- Yael Ziv, Sharon Banin, Dae-Sik Lim, Christine E. Canman, Michael B. Kastan, Yosef Shiloh
Pages 99-108
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- Frank Mercurio, David B. Young, Anthony M. Manning
Pages 109-125
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- Ana Cuenda, Dario R. Alessi
Pages 161-175
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- Jeremy P. Blaydes, Borek Vojtesek, Graham B. Bloomberg, Ted R. Hupp
Pages 177-189
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The Analysis of Stress-Induced Gene Expression
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Front Matter
Pages 202-202
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- Judith M. Mueller, Heike L. Pahl
Pages 205-216
About this book
Mammalian cells have evolved a complex multicomponent machinery that enables them to sense and respond to a wide variety of potentially toxic agents present in their environment. These stress responses are often associated with an increased cellular capacity to tolerate normally lethal levels of an insult. The realization that the mammalian stress response may be intimately linked with many human diseases, including rheumatoid arthritis, ischemia, fever, infection, and cancer, has led to an explosion of interest in this research area. Stress Response: Methods and Protocols brings together a diverse array of practical methodologies that may be employed to address various aspects of the response of mammalian cells to environmental stress. The p- tocols are carefully described by authors who have both devised and succe- fully employed them, and they represent a mixture not only of well-established techniques, but also new technologies at the leading edge of research. The areas covered include the detection and assay of stress-induced damage, the acti- tion of signal transduction pathways, stress-inducible gene expression, and stress protein function. Although no volume of this size can be comprehensive and the topics covered reflect a personal choice, it is hoped that it will prove of subst- tial interest and use to a wide range of research workers in the field.
Reviews
"This handbook will be very helpful in this respect for everybody interested in studies on the effects of stress at the cellular level using biochemical and molecular biology methods." -Cell Biology International
Editors and Affiliations
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ICRF Laboratories, University of Dundee, UK
Stephen M. Keyse
