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Methods in Molecular Medicine

Drug Targeting

Strategies, Principles, and Applications

Editors: Francis, G. E. (Ed.)

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  • ISBN 978-1-59259-075-9
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Hardcover $149.99
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Softcover $149.00
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  • ISBN 978-1-4899-4171-8
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About this book

In Drug Targeting: Strategies, Methods, and Protocls, Gillian E. Francis and Cristina Delgado have assembled an outstanding collection of leading-edge protocols for drug targeting studies. In addition to providing detailed step-by-step instructions, the highly experienced authors review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also presented are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium, as well as methods addressing both the active and passive targeting of tumors.
Comprehensive and innovative, Drug Targeting: Strategies, Methods, and Protocols documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals.

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Chemical Construction of Immunotoxins

    Pages 1-26

    Ghetie, Victor (et al.)

  • Construction of Ribonuclease–Antibody Conjugates for Selective Cytotoxicity

    Pages 27-35

    Newton, Dianne L. (et al.)

  • Intracellular Targeting Using Bispecific Antibodies

    Pages 37-50

    Raso, Vic

  • Antibody Conjugation Methods for Active Targeting of Liposomes

    Pages 51-68

    Ansell, Steven M. (et al.)

  • Folate as a Targeting Device for Proteins Utilizing Folate Receptor-Mediated Endocytosis

    Pages 69-76

    Lee, Robert J. (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-1-59259-075-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-0-89603-531-7
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $149.00
price for USA in USD
  • ISBN 978-1-4899-4171-8
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Drug Targeting
Book Subtitle
Strategies, Principles, and Applications
Editors
  • G. E. Francis
Series Title
Methods in Molecular Medicine
Series Volume
25
Copyright
2000
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-075-9
DOI
10.1385/1592590756
Hardcover ISBN
978-0-89603-531-7
Softcover ISBN
978-1-4899-4171-8
Series ISSN
1543-1894
Edition Number
1
Number of Pages
X, 318
Topics