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Methods in Molecular Biology

Computer Analysis of Sequence Data, Part I

Authors: Griffin, Annette M., Griffin, Hugh G.

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About this book

DNA sequencing has become increasingly efficient over the years, resulting in an enormous increase in the amount of data gen- ated. In recent years, the focus of sequencing has shifted, from being the endpoint of a project, to being a starting point. This is especially true for such major initiatives as the human genome project, where vast tracts of DNA of unknown function are sequenced. This sheer volume of available data makes advanced computer methods ess- tial to analysis, and a familiarity with computers and sequence ana- sis software a vital requirement for the researcher involved with DNA sequencing. Even for nonsequencers, a familiarity with sequence analysis software can be important. For instance, gene sequences already present in the databases can be extremely useful in the design of cloning and genetic manipulation experiments. This two-part work on Analysis of Data is designed to be a practical aid to the researcher who uses computers for the acquisition, storage, or analysis of nucleic acid (and/or p- tein) sequences. Each chapter is written such that a competent sci- tist with basic computer literacy can carry out the procedure successfully at the first attempt by simply following the detailed pr- tical instructions that have been described by the author. A Notes section, which is included at the end of each chapter, provides advice on overcoming the common problems and pitfalls sometimes enco- tered by users of the sequence analysis software. Software packages for both the mainframe and personal computers are described.

Reviews

...the detailed program recipes...will provide a useful adjunct to user manuals.-Nature

Table of contents (29 chapters)

  • Computer Analysis of Sequence Data

    Griffin, Hugh G. (et al.)

    Pages 1-8

  • GCG: Fragment Assembly Programs

    Dölz, Reinhard

    Pages 9-23

  • GCG: Drawing Linear Restriction Maps

    Dölz, Reinhard

    Pages 25-33

  • GCG: Drawing Circular Restriction Maps

    Dölz, Reinhard

    Pages 35-46

  • GCG: Displaying Restriction Sites and Possible Translations in a DNA Sequence

    Dölz, Reinhard

    Pages 47-55

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-59259-511-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $179.00
price for USA in USD
  • ISBN 978-0-89603-246-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Computer Analysis of Sequence Data, Part I
Authors
Series Title
Methods in Molecular Biology
Series Volume
24
Copyright
1994
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-511-2
DOI
10.1385/0896032469
Softcover ISBN
978-0-89603-246-0
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XII, 372
Topics