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Experimental Biology and Medicine

Biology of Copper Complexes

Authors: Sorenson, John R. J.

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About this book

In 1928, it was discovered that copper was essential for normal human metabolism. Ten years later, 1938, it was observed that patients with rheumatoid arthritis had a higher than normal serum copper concentration, which returned to normal wi th remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic diseaseS. The first report that copper complexes had antiinflammatory activity in an animal model of in­ flammation appeared twenty-two years after the discovery of essen­ tiality. In 1976, it was suggested that the active forms of the anti­ arthritic drugs are their copper complexes formed in vivo. This suggestion was confirmed and extended in the interim with over 1000 recent publications, and many of these were addressed in the proceed­ ings of our first symposium, published in 1982. The present symposium was organized to present new normal physiological, nutritional, and biochemical aspects of essential metal­ loelement metabolism as well as variations in metabolism associated with disease states. In addition new data concerning antimicrobial, antiinflammatory, antiulcer, anticancer, anticarcinogenic, analgesic, and radioprotectant activities of copper complexes were presented. These activities are consistent with the notion that they represent the facilitation of normal copper-dependent metabolic processes in dis­ ease states. The presentations and interactive discussions that fol­ lowed are contained in these proceedings. John R. J. Sorenson Dedication These proceedings are dedicated to those who made this truly memorable scientific and social Arkansas experience possible.

Table of contents (48 chapters)

Table of contents (48 chapters)
  • A Physiological Basis for Pharmacological Activities of Copper Complexes: An Hypothesis

    Pages 3-16

    Sorenson, John R. J.

  • Regulation of Ceruloplasmin Synthesis by Retinoic Acid and Interleukin-1

    Pages 17-30

    Cousins, Robert J. (et al.)

  • Role of Ceruloplasmin in Copper Transport

    Pages 31-41

    Harris, Edward D.

  • Copper and the Regulation of Superoxide Dismutase Activity in Aortic Tissue

    Pages 43-55

    Dameron, Charles T. (et al.)

  • Influence of Diet and Inflammation on Serum Copper Enzymes

    Pages 59-66

    Disilvestro, Robert A.

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-4612-4584-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.99
price for USA in USD
  • ISBN 978-0-89603-123-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-1-4612-8937-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Biology of Copper Complexes
Authors
Series Title
Experimental Biology and Medicine
Series Volume
16
Copyright
1987
Publisher
Humana Press
Copyright Holder
The Humana Press Inc.
eBook ISBN
978-1-4612-4584-1
DOI
10.1007/978-1-4612-4584-1
Hardcover ISBN
978-0-89603-123-4
Softcover ISBN
978-1-4612-8937-1
Edition Number
1
Number of Pages
XX, 598
Topics

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