Progress in Gene Expression

Inducible Gene Expression, Volume 1

Environmental Stresses and Nutrients

Editors: Baeuerle, P.A. (Ed.)

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eBook 86,99 €
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  • ISBN 978-1-4684-6840-3
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Softcover 109,19 €
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About this book

Cells have evolved multiple strategies to adapt the composition and quality of their protein equipment to needs imposed by changes in intra- and extracellular conditions. The appearance of pro teins transmit­ ting novel functional properties to cells can be controlled at a transcrip­ tional, posttranscriptional, translational or posttranslational level. Extensive research over the past 15 years has shown that transcriptional regulation is used as the predominant strategy to control the production of new proteins in response to extracellular stimuli. At the level of gene transcription, the initiation ofmRNA synthesis is used most frequently to govern gene expression. The key elements controlling transcription initiation in eukaryotes are activator proteins (transactivators) that bind in a sequence-specific manner to short DNA sequences in the of genes. The activator binding sites are elements of larger proximity control units, ca lied promoters and enhancers, which bind many distinct proteins. These may synergize or negatively cooperate with the activators. The do novo binding of an activator to DNA or, if already bound to DNA, its functional activation is what ultimately turns on a high-level expression of genes. The activity of transactivators is controlled by signalling pathways and, in some cases, transactivators actively partici­ pate in signal transduction by moving from the cytoplasm into the nuc1eus. In this first volume of Inducible Gene Expression, leading scientists in the field review six eukaryotic transactivators that allow cells to respond to various extracellular stimuli by the expression of new proteins.

Table of contents (8 chapters)

  • Prokaryotic control of transcription: How and why does it differ from eukaryotic control?

    Oehler, Stefan (et al.)

    Pages 1-24

    Preview Buy Chapter 30,19 €
  • The Heat Shock Transcriptional Response

    Kroeger, Paul E. (et al.)

    Pages 25-61

    Preview Buy Chapter 30,19 €
  • The Role and Regulation of the Jun Proteins in Response to Phorbol Ester and UV Light

    Angel, Peter

    Pages 62-92

    Preview Buy Chapter 30,19 €
  • NF-κB: A Mediator of Pathogen and Stress Responses

    Siebenlist, Ulrich (et al.)

    Pages 93-141

    Preview Buy Chapter 30,19 €
  • PPAR: a Key Nuclear Factor in Nutrient / Gene Interactions?

    Desvergne, Béatrice (et al.)

    Pages 142-176

    Preview Buy Chapter 30,19 €

Buy this book

eBook 86,99 €
price for Spain (gross)
  • ISBN 978-1-4684-6840-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 103,99 €
price for Spain (gross)
  • ISBN 978-0-8176-3734-7
  • Free shipping for individuals worldwide
  • Currently out of stock.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 109,19 €
price for Spain (gross)
  • ISBN 978-1-4684-6842-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Inducible Gene Expression, Volume 1
Book Subtitle
Environmental Stresses and Nutrients
Editors
  • P.A. Baeuerle
Series Title
Progress in Gene Expression
Copyright
1995
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Boston
eBook ISBN
978-1-4684-6840-3
DOI
10.1007/978-1-4684-6840-3
Hardcover ISBN
978-0-8176-3734-7
Softcover ISBN
978-1-4684-6842-7
Edition Number
1
Number of Pages
284
Topics