Generalized Epilepsy

Neurobiological Approaches

Authors: AVOLI

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About this book

In recent years there has been intense interest in the basic mechanisms of epilepsy. Many symposia and monographs have been devoted to this topic. These reviews, however, have focused almost exclusively on studies performed in models of partial (or focal) epilepsy. It was natural that scientists interested in the fundamental mechanism of epileptogenesis at the cellular level were attracted to work on models in which the epileptogenic dysfunction could be confined to ever-smaller populations of neurons. Many of the most illuminating studies done in this field in the recent past have been carried out in vitro on brain slices or on dissociated neuronal cultures. Much valuable insight into the mechanisms of epileptogenesis has been obtained in this manner. One cannot, however, automatically assume that mechanisms elucidated in such exquisitely "focal" models are applicable to forms of epilepsy in which seizures from their very start involve the entire brain. One of the most difficult questions that arises in this context is how epileptogenic dysfunction, which can be understood in terms of mechanisms involving a few contiguous cells, can lead to what appears to be a simultaneous onset of seizure discharge in virtually all areas of the brain. Most of the workers who have made excellent contributions to the understanding of the cellular mechanisms involved in epileptogenesis have paid virtually no attention to this important problem.

Table of contents (32 chapters)

  • Historical Introduction

    Jasper, H. H.

    Pages 1-15

  • The Syndromes of Generalized Epilepsy

    Dreifuss, F. E.

    Pages 19-29

  • Unanswered Clinical Questions in Generalized Epilepsy

    Andermann, F.

    Pages 30-35

  • The Relationship Between Sleep Spindles and Spike-and-Wave Bursts in Human Epilepsy

    Kellaway, P. (et al.)

    Pages 36-48

  • Membrane Properties of Cat Betz Cells Studied In Vitro

    Crill, W. E. (et al.)

    Pages 51-60

Buy this book

eBook $74.99
price for USA in USD (gross)
  • ISBN 978-1-4684-6767-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA in USD
  • ISBN 978-0-8176-3445-2
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $99.00
price for USA in USD
  • ISBN 978-1-4684-6769-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Generalized Epilepsy
Book Subtitle
Neurobiological Approaches
Authors
Copyright
1990
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Boston, Inc.
eBook ISBN
978-1-4684-6767-3
DOI
10.1007/978-1-4684-6767-3
Hardcover ISBN
978-0-8176-3445-2
Softcover ISBN
978-1-4684-6769-7
Edition Number
1
Number of Pages
XVI, 482
Topics