Developments in Cardiovascular Medicine

Gene Transfer in the Cardiovascular System

Experimental Approaches and Therapeutic Implications

Editors: March, Keith L. (Ed.)

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About this book

The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: • size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . • potential tumorigenesis (e. g. retrovirus) • potential for insertional mutagenesis (greater than plasmid based systems) • potential imrnunogenicity (e. g.

Table of contents (21 chapters)

Table of contents (21 chapters)
  • Development of Viral Vectors for Human Gene Therapy: Retrovirus and Adenovirus (Part I)

    Pages 3-24

    Trapnell, Bruce C., M.D. (et al.)

  • Adenoviruses (Part II): Improvement of Adenoviral Vectors for Human Gene Therapy: E1 and E4 Deleted Recombinant Adenoviruses

    Pages 25-55

    Dedieu, J. F. (et al.)

  • Adeno-Associated Virus and Other New DNA Virus Vectors

    Pages 57-83

    Flotte, Terence R. (et al.)

  • Plasmid and Other Non-Viral Vectors

    Pages 85-110

    Jacobsen, Linda B., Ph.D.

  • The HVJ-Liposome Molecular Delivery System for In Vivo Genetic Engineering

    Pages 111-141

    Gibbons, Gary H., M.D.

Buy this book

eBook $189.00
price for USA in USD
  • ISBN 978-1-4615-6277-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.99
price for USA in USD
  • ISBN 978-0-7923-9859-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $249.99
price for USA in USD
  • ISBN 978-1-4613-7881-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Gene Transfer in the Cardiovascular System
Book Subtitle
Experimental Approaches and Therapeutic Implications
Editors
  • Keith L. March
Series Title
Developments in Cardiovascular Medicine
Series Volume
189
Copyright
1997
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-6277-1
DOI
10.1007/978-1-4615-6277-1
Hardcover ISBN
978-0-7923-9859-2
Softcover ISBN
978-1-4613-7881-5
Series ISSN
0166-9842
Edition Number
1
Number of Pages
XX, 516
Topics