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In Situ Hybridization: Medical Applications

Editors: Coulton, G.R., Belleroche, J. de (Eds.)

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About this book

In situ hybridization has developed as a means of localizing specific DNA and RNA sequences within tissues. The great strength of this approach is the ability to relate the distribution of specific nucleic acids with cell structures and the protein products of the target gene by means of immunohistochemistry. Complementary DNA, RNA or oligonucleotide probes, suitably labelled, are hybridized to specific DNA or RNA targets within tissues. The spatial information thus obtained has contributed greatly to our understanding of such diverse areas of research as gene mapping, viral infection, cytogenetics, protein synthesis, prenatal diagnosis and tissue grafting.
This book is not intended as another recipe book, although it does describe theoretical and practical aspects of the technology. Rather, the authors critically describe the contribution made by in situ hybridization to specific areas of medical research.

Table of contents (5 chapters)

Table of contents (5 chapters)
  • Techniques for in situ hybridization histochemistry

    Pages 1-36

    McCafferty, John (et al.)

  • Use of comparative in situ hybridization and immunocytochemistry for the study of regulatory peptides

    Pages 37-51

    Terenghi, Giorgio (et al.)

  • Application of in situ hybridization to studies of messenger RNA in the nervous system: functional correlations and their quantitation

    Pages 52-65

    Belleroche, J. (et al.)

  • The use of in situ hybridization in studies of viral disease

    Pages 66-96

    Morey, Adrienne L. (et al.)

  • In situ hybridization for molecular cytogenetics

    Pages 97-109

    Raap, A. K. (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-94-011-2984-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
Softcover $139.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
In Situ Hybridization: Medical Applications
Editors
  • G.R. Coulton
  • J. de Belleroche
Copyright
1992
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-011-2984-8
DOI
10.1007/978-94-011-2984-8
Hardcover ISBN
978-0-7923-8989-7
Softcover ISBN
978-94-010-5326-6
Edition Number
1
Number of Pages
XII, 116
Topics

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