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Progress in Experimental Cardiology

Angiotensin II Receptor Blockade Physiological and Clinical Implications

Editors: Dhalla, N.S., Zahradka, P., Dixon, I.M.C., Beamish, R.E. (Eds.)

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eBook $269.00
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Hardcover $389.00
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Softcover $349.99
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  • ISBN 978-1-4613-7631-6
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About this book

The relationship between angiotensin II and hypertension was established in 1898 when angiotensin II was shown to modulate systemic blood pressure. Over the intervening decades, a complete characterization of the renin-angiotensin system (RAS) has been achieved, and our understanding of its biochemistry and physiology has led to the directed development of agents such ·as ACE inhibitors and receptor antagonists capable of controlling hypertension. More recently, it was shown that angiotensin II is secreted within certain tissues and that these tissue-specific systems operate independently of the systemic RAS. The novel concept that angiotensin II regulates a number of cardiovascular processes that are unrelated to blood pressure has renewed the interest of both basic and clinical scientists in angiotensin II. The association between angiotensin II and cardiac growth, in particular, has indicated that therapies currently in use for hypertension may have direct application to the treatment of heart failure. The Manitoba Cardiovascular Forum on Angiotensin Receptor Blockade in Winnipeg was convened October 18-20, 1996 to examine the clinical and basic aspects of angiotensin receptor biology as they apply to hypertension and heart failure. In addition, the potential treatment of these conditions using specific angio­ tensin receptor antagonists was addressed within the context of their immediate therapeutic application and future potential.

Table of contents (42 chapters)

  • Pharmacological Interruption Of The Renin System And The Kidney: Lessons From Comparative Pharmacology

    Hollenberg, Norman K.

    Pages 3-13

  • The Brain Renin-Angiotensin System And Salt-Sensitive Hypertension

    Veerasingham, Shereeni J. (et al.)

    Pages 15-32

  • At1 Angiotensin Receptor Blockade and Angiotensin Converting Enzyme Inhibition: Effects on Vascular Remodeling and Endothelial Dysfunction in Shr

    Schiffrin, Ernesto L. (et al.)

    Pages 33-40

  • Cellular Physiology of Angiotensin II Receptors in Vascular Smooth Muscle Cells

    Zahradka, P. (et al.)

    Pages 41-50

  • Angiotensin II Enhanced The Expression Of Inhibitory Guanine Nucleotide Regulatory Protein in Vascular Smooth Muscle Cells: Blockade By at1 Antagonist

    Anand-Srivastava, Madhu B. (et al.)

    Pages 51-64

Buy this book

eBook $269.00
price for USA in USD (gross)
  • ISBN 978-1-4615-5743-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $389.00
price for USA in USD
  • ISBN 978-0-7923-8147-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $349.99
price for USA in USD
  • ISBN 978-1-4613-7631-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Angiotensin II Receptor Blockade Physiological and Clinical Implications
Editors
  • Naranjan S. Dhalla
  • Peter Zahradka
  • Ian M.C. Dixon
  • Robert E. Beamish
Series Title
Progress in Experimental Cardiology
Series Volume
2
Copyright
1998
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-5743-2
DOI
10.1007/978-1-4615-5743-2
Hardcover ISBN
978-0-7923-8147-1
Softcover ISBN
978-1-4613-7631-6
Series ISSN
1389-1774
Edition Number
1
Number of Pages
XLIII, 588
Topics