Heart Cell Communication in Health and Disease

1. Front Matter

   Pages i-xiii

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2. On the Syncytial Nature of Cardiac Muscle

   • Walmor C. De Mello

   Pages 1-17

3. Gap Junctions and Heart Development

   • Robert G. Gourdie, Wanda H. Litchenberg, Leonard M. Eisenberg

   Pages 19-43

4. Cardiovascular Gap Junction Proteins: Molecular Characterization and Biochemical Regulation

   • Eric C. Beyer, Kyung Hwan Seul, David M. Larson

   Pages 45-72

5. Biophysics of Gap Junction Channels

   • Richard D. Veenstra, Hong-Zhan Wang

   Pages 73-103

6. On the Control of Junctional Conductance

   • Walmor C. De Mello

   Pages 105-124

7. Gap Junctions and the Spread of Electrical Excitation

   • Robin Shaw, Yoram Rudy

   Pages 125-147

8. Cell to Cell Communication in the Failing Heart

   • Walmor C. De Mello

   Pages 149-173

9. Gap Junctions and Coronary Heart Disease

   • Nicholas J. Severs

   Pages 175-194

10. Cellular Electrical Uncoupling During Ischemia

    • Michiel J. Janse, Hanno L. Tan, Lukas R. C. Dekker, André G. Kléber

    Pages 195-216

11. Gap Junctions, Cardiac Excitability and Clinical Arrhythmias

    • Morton F. Arnsdorf, Samuel C. Dudley

    Pages 217-288

12. Back Matter

    Pages 289-295

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In Heart Cell Communication in Health and Disease an extensive review of different aspects of heart cell communication is presented. The book starts with the fundamental concept that cardiac cells are communicated, and then proceeds to the role of gap junctions in heart development, the molecular biology of gap junctions, the biophysics of the intercellular channels, the control of junctional conductance and the influence of gap junctions on impulse propagation.
This is the first time that a single volume has described cell communication in the normal heart and under different pathological conditions such as heart failure, coronary disease, myocardial ischemia and cardiac arrhythmias. In this way the process of cell communication is analyzed at different levels of complexity, providing the reader with a wide view of this field and its relevance to cardiology.

• arrhythmia
• biology
• cardiology
• cardiovascular
• cells
• coronary heart disease
• heart
• heart disease
• heart failure

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