Arterial Remodeling: A Critical Factor in Restenosis

1. Front Matter

   Pages i-xxix

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2. Basis of the concept

   1. Front Matter

      Pages 1-1

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   2. Restenosis: Prevention of a Complete Stabilizing Remodeling Response to Wall Shear and Tensile Stress Following Direct Interventions on Plaques

      • Seymour Glagov, Hisham S. Bassiouny

      Pages 3-20

   3. Constrictive Remodeling: Do Concepts of Remodeling During Chronic Hypertension Apply to Restenosis?

      • Jean-Marc Chillon, Gary L. Baumbach

      Pages 21-30

   4. Growth and Remodeling of Coronary Collateral Vessels

      • Wolfgang Schaper, Dimitri Scholz

      Pages 31-48

3. Restenosis and remodeling: the facts

   1. Front Matter

      Pages 49-49

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   2. Experimental Evidence of Remodeling after Angioplasty

      • A. Lafont, E. Durand, S. Drechsel, K. Bougrini, M. Desnos, C. Guérot

      Pages 51-68

   3. Remodeling: Accelerator or Decelerator of Luminal Narrowing in Human Atherosclerotic Arteries

      • Gerard Pasterkamp, Berend Hillen, Cornelius Borst

      Pages 69-80

   4. Histologic Basis of Vessel Remodeling after Various Interventional Procedures: A Comparison of Acute (Cracks, Breaks, Tears, Stretching) and Chronic (Tissue Proliferation, Recoil) Changes

      • Bruce F. Waller, Charles M. Orr, James Van Tassel, Thomas Peters, Edward Fry, James Hermiller

      Pages 81-110

   5. Serial Intravascular Ultrasound Evidence for Arterial Remodeling as a Mechanism of Restenosis Following Interventional Coronary Procedures

      • Gary S. Mintz, Jeffrey J. Popma, Augusto D. Pichard, Kenneth M. Kent, Lowell F. Satler, Martin B. Leon

      Pages 111-126

   6. Coronary Blood Flow During Interventional Procedures: Implications for Vascular Remodeling

      • Morton J. Kern

      Pages 127-158

4. Restenosis and remodeling: the targets revisited

   1. Front Matter

      Pages 159-159

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   2. Restenosis and Remodeling: Is the Adventitia Involved?

      • Jean Grégoire, Michael E. Staab, David R. Holmes Jr., Robert S. Schwartz

      Pages 161-180

   3. Post-Angioplasty Smooth Muscle Cell Apoptosis

      • Gerhard Bauriedel, Sven Schluckebier, Randolph Hutter, Ulrich Welsch, Berndt Lüderitz

      Pages 181-198

   4. Intimal Hyperplasia is the Wrong Target: Restenosis as a Failure of Remodeling

      • Randolph L. Geary, Stephen M. Schwartz

      Pages 199-230

   5. Endothelial Dysfunction after Angioplasty: A Pathway for Remodelling?

      • Thomas F. Lüscher, Georg Noll, Chantal M. Boulanger

      Pages 231-252

5. Molecular aspects of remodeling

   1. Front Matter

      Pages 253-253

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   2. Vascular Remodeling and Lesion Formation in Restenosis: Implications for Nitric Oxide-Based Therapeutics

      • Gary H. Gibbons

      Pages 255-276

   3. Oxidative Stress and Vascular Remodeling

      • Bradford C. Berk

      Pages 277-304

   4. Matrix Metalloproteinases in Injured Artery

      • Eric Allaire, Peter Libby, Alexander W. Clowes

      Pages 305-338

Angioplasty has completely transformed the treatment of coronary artery disease and is widely used, with more than 800,000 procedures performed worldwide per year. However, the enthusiasm for angioplasty is shadowed by restenosis, which remains a critical problem after the procedure, resulting in clinical recurrence in over a third of patients. Recently, the mechanisms of restenosis have been completely reappraised with an enriched understanding that the original concept of neointimal hyperplasia may not be accounting for the bulk of the problem.
There is a desperate need to heighten understanding of the remodeling process at the molecular, cellular, and arterial level. Vascular remodeling is a well established concept in the field of atherosclerosis and hypertension, but only in recent years has its applicability to the field of restenosis become pivotal. Accordingly, the editors perceived the need to assemble the first book dedicated to the concept of coronary artery remodeling in restenosis, in order to clearly review the experiments leading to the remodeling hypothesis and integrate this with the neointimal hyperplasia (tumor) model for the development of the restenotic lesion.
The authors of this book present their experience to facilitate the understanding of the mechanisms for coronary restenosis and remodeling. The various experimental models, clinical issues, and basic mechanisms are reviewed in detail, resulting in a fresh approach to a vexing clinical problem. Arterial Remodeling: A Critical Factor in Restenosis will be useful to the physician and trainee who have an interest in restenosis, and specifically in the major pathophysiologic process which determines the fate of arterial healing in patients following percutaneous coronary revascularization. It is hoped that this book will lay the foundation for more effective therapies that will reduce the chance of constrictive remodeling and improve the long-term efficacy of non-surgical coronary revascularization in the future.

• Lipoprotein
• Stent
• atherosclerosis
• coronary artery disease
• hypertension
• ultrasound

• Necker University, Paris, France

  Antoine Lafont

• Cleveland Clinic Foundation, Cleveland, USA

  Eric J. Topol

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